PEBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEBP1_MOUSE
• UniProt AC: P70296
• Protein Name: Phosphatidylethanolamine-binding protein 1
• Gene Name: Pebp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 187
• Subcellular Localization: Cytoplasm.
• Protein Description: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).; HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor (By similarity)..
• Protein Sequence: MAADISQWAGPLCLQEVDEPPQHALRVDYAGVTVDELGKVLTPTQVMNRPSSISWDGLDPGKLYTLVLTDPDAPSRKDPKFREWHHFLVVNMKGNDISSGTVLSDYVGSGPPSGTGLHRYVWLVYEQEQPLSCDEPILSNKSGDNRGKFKVETFRKKYNLGAPVAGTCYQAEWDDYVPKLYEQLSGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADISQWA ------CCCCHHHHC	17.53	-
6	Phosphorylation	--MAADISQWAGPLC --CCCCHHHHCCCCC	21.88	29514104
13	S-palmitoylation	SQWAGPLCLQEVDEP HHHCCCCCCCCCCCC	4.08	28680068
42	Phosphorylation	DELGKVLTPTQVMNR HHHCCCCCCHHHHCC	27.55	24925903
44	Phosphorylation	LGKVLTPTQVMNRPS HCCCCCCHHHHCCCC	28.67	24925903
51	Phosphorylation	TQVMNRPSSISWDGL HHHHCCCCCCCCCCC	36.75	25521595
52	Phosphorylation	QVMNRPSSISWDGLD HHHCCCCCCCCCCCC	24.27	25521595
54	Phosphorylation	MNRPSSISWDGLDPG HCCCCCCCCCCCCCC	22.51	25521595
64	Phosphorylation	GLDPGKLYTLVLTDP CCCCCCEEEEEEECC	11.08	26160508
65	Phosphorylation	LDPGKLYTLVLTDPD CCCCCEEEEEEECCC	22.34	21183079
77	Ubiquitination	DPDAPSRKDPKFREW CCCCCCCCCCCCCCC	80.75	22790023
98	Phosphorylation	NMKGNDISSGTVLSD ECCCCCCCCCCCCCC	26.11	-
99	Phosphorylation	MKGNDISSGTVLSDY CCCCCCCCCCCCCCC	38.53	28464351
106	Phosphorylation	SGTVLSDYVGSGPPS CCCCCCCCCCCCCCC	11.88	23984901
109	Phosphorylation	VLSDYVGSGPPSGTG CCCCCCCCCCCCCCC	37.77	19060867
113	Phosphorylation	YVGSGPPSGTGLHRY CCCCCCCCCCCCHHE	52.71	25521595
115	Phosphorylation	GSGPPSGTGLHRYVW CCCCCCCCCCHHEEE	40.69	19060867
125	Phosphorylation	HRYVWLVYEQEQPLS HHEEEEEEECCCCCC	15.10	23140645
132	Phosphorylation	YEQEQPLSCDEPILS EECCCCCCCCCCCCC	26.63	21082442
133	S-nitrosylation	EQEQPLSCDEPILSN ECCCCCCCCCCCCCC	10.14	22178444
133	Glutathionylation	EQEQPLSCDEPILSN ECCCCCCCCCCCCCC	10.14	24333276
133	S-nitrosocysteine	EQEQPLSCDEPILSN ECCCCCCCCCCCCCC	10.14	-
139	Phosphorylation	SCDEPILSNKSGDNR CCCCCCCCCCCCCCC	42.82	25293948
150	Acetylation	GDNRGKFKVETFRKK CCCCCCEEEEEHHHH	42.52	22826441
153	Phosphorylation	RGKFKVETFRKKYNL CCCEEEEEHHHHCCC	31.56	21183079
156	Acetylation	FKVETFRKKYNLGAP EEEEEHHHHCCCCCC	56.25	22826441
157	Acetylation	KVETFRKKYNLGAPV EEEEHHHHCCCCCCC	34.81	22826441
168	S-nitrosylation	GAPVAGTCYQAEWDD CCCCCCEEEECCHHH	2.01	21278135
168	S-palmitoylation	GAPVAGTCYQAEWDD CCCCCCEEEECCHHH	2.01	28526873
168	S-nitrosocysteine	GAPVAGTCYQAEWDD CCCCCCEEEECCHHH	2.01	-
176	Phosphorylation	YQAEWDDYVPKLYEQ EECCHHHHHHHHHHH	19.04	29514104
181	Phosphorylation	DDYVPKLYEQLSGK- HHHHHHHHHHHCCC-	14.04	22499769
185	Phosphorylation	PKLYEQLSGK----- HHHHHHHCCC-----	44.20	25521595
187	Ubiquitination	LYEQLSGK------- HHHHHCCC-------	54.51	-
187	Acetylation	LYEQLSGK------- HHHHHCCC-------	54.51	7744109

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEBP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RAF1_MOUSE	Raf1	physical	23055494
MP2K1_MOUSE	Map2k1	physical	23055494

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51; SER-52 AND SER-54,AND MASS SPECTROMETRY.
PubMed: 17242355