| UniProt ID | PEX6_MOUSE | |
|---|---|---|
| UniProt AC | Q99LC9 | |
| Protein Name | Peroxisome assembly factor 2 | |
| Gene Name | Pex6 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 981 | |
| Subcellular Localization | Cytoplasm. Peroxisome membrane . Cell projection, cilium, photoreceptor outer segment . Associated with peroxisomal membranes (By similarity). Localized at the base of the outer segment of photoreceptor cells (PubMed:26593283). | |
| Protein Description | Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity).. | |
| Protein Sequence | MALAVLRVLDPFPTETPPLAVLLPPGGPWPATGLGLVLALRPASESPAKPALLVAAVEGSGAQGEQRGPGPPPLLVSRALLRVLALGPGARVRARLVRRPPALGWALLATAPGPGLGPRVGPLLVRRGETLPVPGSRVLETRPALQGLLGPGTRLAVTELRGRAKLGQESRDHSHPPPPPVVSSFAASHSVRRLRGVLGGTGDALGVSRSCLRSLGLFQGEWVWVAQVAELPNSSQPRLAQVQVLEPRWELSERLGPNSGQQPGEPLADGLVFLPATLAFNLGCDPLEVGELRIQRYLEGSIAPENKGSCSPLPGPPFARELHIEILSSPHYSANGNYDHVLYRHFQTPRVVQEGDVLCVSTAGQVEILEGSLERLPRWREMFFKVKKTVGEAPEGPASAFLADTTHTSLYLAGTALSHVPSLPSGRSPPWDSLSPPGLEALVNELCAILKPHLQPGGTLLTGTSCVLLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRAVETKLQATFSRARRCRPAVLLLTAVDLLGRDRDGLGEDARVAATLRHLLLDEDALSRCPPLMVVATTSRVQDLPTDVQTAFPHELEVPVLSEAQRLSILQALTAHLPLGQEVNLPQLARRCAGFVVGDLYALLTHTCRAACTRIRASGSAGGLSEEDEGDLCVAGFPLLAEDFGQALDQLQTAHSQAVGAPRIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGASEDRASQLRVLSAITRKFKLEASVSLANVLDCCPPQLTGADLYSLCSDAMMTALKRRVRDLEEGLELRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFAAC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 119 | Methylation | PGPGLGPRVGPLLVR CCCCCCCCCCCEEEE | 44.20 | - | |
| 130 | Phosphorylation | LLVRRGETLPVPGSR EEEECCCCCCCCCCC | 38.90 | 28285833 | |
| 307 | Ubiquitination | GSIAPENKGSCSPLP CCCCCCCCCCCCCCC | 51.01 | - | |
| 511 | Ubiquitination | SSRAVETKLQATFSR CCHHHHHHHHHHHHH | 25.70 | - | |
| 515 | Phosphorylation | VETKLQATFSRARRC HHHHHHHHHHHHHCH | 14.80 | 23140645 | |
| 551 | Phosphorylation | EDARVAATLRHLLLD HHHHHHHHHHHHHCC | 18.00 | 26239621 | |
| 563 | Phosphorylation | LLDEDALSRCPPLMV HCCHHHHHCCCCEEE | 33.29 | 26239621 | |
| 715 | Ubiquitination | VGGLQDVKKEILETI CCCHHHHHHHHHHHC | 53.64 | - | |
| 962 | Phosphorylation | AAARLQPSVSEQELL HHHHHCCCCCHHHHH | 25.89 | 28285833 | |
| 964 | Phosphorylation | ARLQPSVSEQELLRY HHHCCCCCHHHHHHH | 37.59 | 28285833 | |
| 971 | Phosphorylation | SEQELLRYKRIQRKF CHHHHHHHHHHHHHH | 12.46 | 28285833 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PEX6_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PEX6_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PEX6_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PEX6_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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