CD22_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CD22_MOUSE
• UniProt AC: P35329
• Protein Name: B-cell receptor CD22
• Gene Name: Cd22
• Organism: Mus musculus (Mouse).
• Sequence Length: 862
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules..
• Protein Sequence: MRVHYLWLLLILGHAASAQYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFKGTVLYNKAEPELYPPKQRRVTFLGNSIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFEYDILLQWFLEDSKITSVTPSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSEVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDMHNAGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	N-linked_Glycosylation	FLGNSIDNCTLKIHP EECCCCCCCEEEEEE	21.00	-
116	N-linked_Glycosylation	KIHPIRANDSGNLGL EEEEECCCCCCCCCC	33.85	-
139	N-linked_Glycosylation	WMEPIHLNVSEKPFQ CCCCEEECCCCCCCC	22.55	-
141	Phosphorylation	EPIHLNVSEKPFQPY CCEEECCCCCCCCCC	38.54	28464351
168	N-linked_Glycosylation	VTLTCGLNFSCFEYD EEEEEECCEEEEEHH	16.45	-
265	N-linked_Glycosylation	NPTEVEKNNSVTMTC CCCCEECCCEEEEEE	32.29	-
275	N-linked_Glycosylation	VTMTCRVNSSNPKLR EEEEEEECCCCCCEE	21.99	-
378	N-linked_Glycosylation	LASPSATNYTWYHNR CCCCCCCCCCEECCC	31.77	-
408	N-linked_Glycosylation	VSPWHAGNYSCLAEN CCCCCCCCCCHHHCC	26.74	-
460	N-linked_Glycosylation	VTLVCRYNSSNPDVT EEEEEECCCCCCCCC	21.43	-
561	N-linked_Glycosylation	VRFFWKKNGSLVQEG EEEEEEECCCEEEEC	41.37	-
589	N-linked_Glycosylation	GNYNCMVNNSIGETL CCCEEEECCCHHHHH	15.06	-
669	Phosphorylation	EPLEVQHTGSYRCKG CEEECEECCCEECCC	15.67	21183079
671	Phosphorylation	LEVQHTGSYRCKGTN EECEECCCEECCCCC	15.57	21183079
672	Phosphorylation	EVQHTGSYRCKGTNG ECEECCCEECCCCCC	22.75	21183079
740	Phosphorylation	QQGLQENSSGQSFFV HHCCCCCCCCCCEEE	34.78	24704852
741	Phosphorylation	QGLQENSSGQSFFVR HCCCCCCCCCCEEEC	53.05	24704852
744	Phosphorylation	QENSSGQSFFVRNKK CCCCCCCCEEECCCC	24.95	24704852
767	Phosphorylation	GPQSQGCYNPAMDDT CCCCCCCCCCCCCCC	30.88	-
777	Phosphorylation	AMDDTVSYAILRFPE CCCCCEEEEEEECCH	8.04	18024433
811	Phosphorylation	NNSDSVTYSVIQKRP CCCCCCEEEEEECCC	9.97	18024433
822	Phosphorylation	QKRPMGDYENVNPSC ECCCCCCCCCCCCCC	12.04	24224561
837	Phosphorylation	PEDESIHYSELVQFG CCCCCCCHHHHHHCC	11.36	18024433
838	Phosphorylation	EDESIHYSELVQFGA CCCCCCHHHHHHCCC	15.42	24224561
857	Phosphorylation	QAKEDVDYVTLKH-- CCCCCCCEEEECC--	8.65	24704852

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CD22_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CD22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CD22_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_MOUSE	Grb2	physical	10373493
P85A_MOUSE	Pik3r1	physical	10373493
KSYK_MOUSE	Syk	physical	10373493
PLCG1_MOUSE	Plcg1	physical	10373493

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.