MMS22_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MMS22_MOUSE
• UniProt AC: B1AUR6
• Protein Name: Protein MMS22-like
• Gene Name: Mms22l
• Organism: Mus musculus (Mouse).
• Sequence Length: 1238
• Subcellular Localization: Nucleus. Localizes to DNA damage sites, accumulates at stressed replication forks..
• Protein Description: Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity)..
• Protein Sequence: MDGCSAASTFLTDSLELELGTEWCKPPCFSCAFDNREGKFSGESYLASGALKRLILNLDPLPTNFEEDTVELFGFQWVTETALVYSCRELFHLFRQQIFNLESLVQVSCDFGKIATLHAKADSIRQQCVVFLHYIKVFIFRCLKVQEAESHSRPAHPYEALEAQLPSMLVDELRGLLLYIGHLAALPSVTVGAFVNQNQMKLFPPSWHLLHLYLDTHWLVLEILHILGEKLKQVVYGRQFIGQAGDNLTNVSLFEEHCEHLFCDLICLSLNRFDKVMPSEALLISHCPCSCVKELWVLLIHLLDHRRKWSVADSFWNWLNKLLRTLFEKSSDQRRSSVSLTQAKDPLGFSWWISVHVASLYQIDRHGVSDKMKQMESNWSFIEELLKRSVTVQDSILEEQLRMHLHCCLTLCDFWEPNISVVTILWEYYSKNLNSSFSISWLPLKGLTNIIKSPLSMLTLVRNCCSDKQDPDLYKSSSSYIIFLCILAKVVKKAMRTSGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEIEDVASHVLDLLRFLRPASMSSHGALVWKGQMAFLLMYAQKNLDIGVWAEKLSCEFQEKAKEFLVSKNDEMVQRHALWTLLCIYIDGVQEVFETSSCLYPSHEHLLNDGFSMLLPACRESELRTVLNFLQAVLARIRSVHQQLCQELQRENVDLTVQSSLSAKERPLAAVAGALWRHFFSFLKSQRMTQVVPLSQLADAAADFTLLAVDMPNTAPPDLQPQPVISIIQLFGWDDIIWPQVVARYLSHLLQNSTVYEALSQSSCVSSQSLTIRSWVRCVLQMHIKHLSDPDLLIDVNPEQAVEKEYMEQLAEMTRLLFTLSEVKSVFSKAQIEQLPSPDDPKQALIQFLEAVGVTYRTLQTFSDKSAMVTKSLEYLGEVLKYIKPYLGKKVSSAGLQLTYGIMGILVKSWAHIFATSKAQKLLFRIIDCLLLPHTVLQQDKELPGPMLTAIQKTLPLYLQGICIVCCQSQNPNAYLNQLLRNVIEQYIGRFLPTSPCVSDLGQHPVLLALRNPASVPSMTPLRKHTVHAIRKSYLEFKGSSPPPRLASVLAFVLQLFKDTEMGACDLELLLPGILKCLVLVNEPQVKKLATENLQCMVQTCQVGSEGGPATQLTSLFRQFIQDYGMQYSYQVYSILETVATLNQHVVIQLIPTLTQSLKDSELKWGLGRNIAQREAYSRLLSGLGQVGQGEKQRLEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
336	Phosphorylation	KSSDQRRSSVSLTQA CCCCCCCCCCCCCCC	36.96	25338131
337	Phosphorylation	SSDQRRSSVSLTQAK CCCCCCCCCCCCCCC	17.57	25338131
662	Phosphorylation	LLPACRESELRTVLN HHHHHCHHHHHHHHH	23.68	29899451
847	Phosphorylation	EQAVEKEYMEQLAEM HHHHCHHHHHHHHHH	19.61	28576409
862	Phosphorylation	TRLLFTLSEVKSVFS HHHHHHHHHHHHHHC	36.97	24899341
865	Ubiquitination	LFTLSEVKSVFSKAQ HHHHHHHHHHHCHHH	36.53	22790023
913	Phosphorylation	KSAMVTKSLEYLGEV CCHHHHHHHHHHHHH	19.64	28066266
916	Phosphorylation	MVTKSLEYLGEVLKY HHHHHHHHHHHHHHH	25.87	28066266
1082	Phosphorylation	YLEFKGSSPPPRLAS HHHHCCCCCCHHHHH	50.52	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MMS22_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MMS22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MMS22_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MMS22_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.