MMS22_MOUSE - dbPTM
MMS22_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MMS22_MOUSE
UniProt AC B1AUR6
Protein Name Protein MMS22-like
Gene Name Mms22l
Organism Mus musculus (Mouse).
Sequence Length 1238
Subcellular Localization Nucleus. Localizes to DNA damage sites, accumulates at stressed replication forks..
Protein Description Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity)..
Protein Sequence MDGCSAASTFLTDSLELELGTEWCKPPCFSCAFDNREGKFSGESYLASGALKRLILNLDPLPTNFEEDTVELFGFQWVTETALVYSCRELFHLFRQQIFNLESLVQVSCDFGKIATLHAKADSIRQQCVVFLHYIKVFIFRCLKVQEAESHSRPAHPYEALEAQLPSMLVDELRGLLLYIGHLAALPSVTVGAFVNQNQMKLFPPSWHLLHLYLDTHWLVLEILHILGEKLKQVVYGRQFIGQAGDNLTNVSLFEEHCEHLFCDLICLSLNRFDKVMPSEALLISHCPCSCVKELWVLLIHLLDHRRKWSVADSFWNWLNKLLRTLFEKSSDQRRSSVSLTQAKDPLGFSWWISVHVASLYQIDRHGVSDKMKQMESNWSFIEELLKRSVTVQDSILEEQLRMHLHCCLTLCDFWEPNISVVTILWEYYSKNLNSSFSISWLPLKGLTNIIKSPLSMLTLVRNCCSDKQDPDLYKSSSSYIIFLCILAKVVKKAMRTSGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEIEDVASHVLDLLRFLRPASMSSHGALVWKGQMAFLLMYAQKNLDIGVWAEKLSCEFQEKAKEFLVSKNDEMVQRHALWTLLCIYIDGVQEVFETSSCLYPSHEHLLNDGFSMLLPACRESELRTVLNFLQAVLARIRSVHQQLCQELQRENVDLTVQSSLSAKERPLAAVAGALWRHFFSFLKSQRMTQVVPLSQLADAAADFTLLAVDMPNTAPPDLQPQPVISIIQLFGWDDIIWPQVVARYLSHLLQNSTVYEALSQSSCVSSQSLTIRSWVRCVLQMHIKHLSDPDLLIDVNPEQAVEKEYMEQLAEMTRLLFTLSEVKSVFSKAQIEQLPSPDDPKQALIQFLEAVGVTYRTLQTFSDKSAMVTKSLEYLGEVLKYIKPYLGKKVSSAGLQLTYGIMGILVKSWAHIFATSKAQKLLFRIIDCLLLPHTVLQQDKELPGPMLTAIQKTLPLYLQGICIVCCQSQNPNAYLNQLLRNVIEQYIGRFLPTSPCVSDLGQHPVLLALRNPASVPSMTPLRKHTVHAIRKSYLEFKGSSPPPRLASVLAFVLQLFKDTEMGACDLELLLPGILKCLVLVNEPQVKKLATENLQCMVQTCQVGSEGGPATQLTSLFRQFIQDYGMQYSYQVYSILETVATLNQHVVIQLIPTLTQSLKDSELKWGLGRNIAQREAYSRLLSGLGQVGQGEKQRLEK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
336PhosphorylationKSSDQRRSSVSLTQA
CCCCCCCCCCCCCCC
36.9625338131
337PhosphorylationSSDQRRSSVSLTQAK
CCCCCCCCCCCCCCC
17.5725338131
662PhosphorylationLLPACRESELRTVLN
HHHHHCHHHHHHHHH
23.6829899451
847PhosphorylationEQAVEKEYMEQLAEM
HHHHCHHHHHHHHHH
19.6128576409
862PhosphorylationTRLLFTLSEVKSVFS
HHHHHHHHHHHHHHC
36.9724899341
865UbiquitinationLFTLSEVKSVFSKAQ
HHHHHHHHHHHCHHH
36.5322790023
913PhosphorylationKSAMVTKSLEYLGEV
CCHHHHHHHHHHHHH
19.6428066266
916PhosphorylationMVTKSLEYLGEVLKY
HHHHHHHHHHHHHHH
25.8728066266
1082PhosphorylationYLEFKGSSPPPRLAS
HHHHCCCCCCHHHHH
50.5225159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MMS22_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MMS22_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MMS22_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MMS22_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MMS22_MOUSE

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Related Literatures of Post-Translational Modification

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