MFN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFN1_MOUSE
• UniProt AC: Q811U4
• Protein Name: Mitofusin-1
• Gene Name: Mfn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 741
• Subcellular Localization: Mitochondrion outer membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. [PubMed: 12527753]
• Protein Sequence: MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIASEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPSEARNRIFFVSAKEVLNSRKHKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTNEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVSFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLESELENFSKQFLHPSSGES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MAETVSPLKHFVL --CCCCCCHHHHHHH	31.75	25338131
133	Ubiquitination	MTEGSDEKKSVKTVN EECCCCCHHHHHHHH	56.17	-
228	Phosphorylation	HKVNERLSKPNIFIL HHHHHHCCCCCEEEE	52.89	23737553
229	Ubiquitination	KVNERLSKPNIFILN HHHHHCCCCCEEEEC	46.83	-
272	Phosphorylation	VEELKVVSPSEARNR HHHCCCCCHHHHHCC	26.20	20415495
274	Phosphorylation	ELKVVSPSEARNRIF HCCCCCHHHHHCCEE	36.06	20415495
395	Ubiquitination	NLLTLDVKKKIKEVT HHHHHHHHHHHHHHH	48.27	27667366
396	Acetylation	LLTLDVKKKIKEVTE HHHHHHHHHHHHHHH	60.63	7920775
396	Ubiquitination	LLTLDVKKKIKEVTE HHHHHHHHHHHHHHH	60.63	-
397	Acetylation	LTLDVKKKIKEVTEE HHHHHHHHHHHHHHH	53.98	7921001
399	Ubiquitination	LDVKKKIKEVTEEVA HHHHHHHHHHHHHHH	55.82	-
590	Phosphorylation	TLITGLASLTSRTSM HHHHHHHHHCCCCCC	36.90	27180971
592	Phosphorylation	ITGLASLTSRTSMGI HHHHHHHCCCCCCEE	17.42	29472430
681	S-nitrosocysteine	ATTFARLCQQVDVTQ HHHHHHHHHHCCCHH	1.90	-
681	S-nitrosylation	ATTFARLCQQVDVTQ HHHHHHHHHHCCCHH	1.90	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Marchf5	Q3KNM2	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MFN2_MOUSE	Mfn2	physical	12527753
MGRN1_MOUSE	Mgrn1	physical	27713096

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.