MFN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFN2_MOUSE
• UniProt AC: Q80U63
• Protein Name: Mitofusin-2
• Gene Name: Mfn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 757
• Subcellular Localization: Mitochondrion outer membrane ; Multi-pass membrane protein . Colocalizes with BAX during apoptosis.
• Protein Description: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. [PubMed: 12527753]
• Protein Sequence: MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSMVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERQFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNLSDRCSTAIASSLQTMQQDMIDGLKPLLPVSMRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYSDQVQRPLPLTPANPSMPPLPQSSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSRAKLLRNKAGWLDSELNMFTHQYLQPSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLFSRCN ------CCCCCCCCC	33.51	26643407
6	Phosphorylation	--MSLLFSRCNSIVT --CCCCCCCCCEEEE	35.57	26643407
10	Phosphorylation	LLFSRCNSIVTVKKD CCCCCCCEEEEEECC	23.28	23737553
13	Phosphorylation	SRCNSIVTVKKDKRH CCCCEEEEEECCHHH	25.57	22324799
27	Phosphorylation	HMAEVNASPLKHFVT HHCCCCCCHHHHHHH	26.09	28066266
30	Ubiquitination	EVNASPLKHFVTAKK CCCCCHHHHHHHHHH	38.08	-
84	Ubiquitination	DVKGYLSKVRGISEV CHHHHHHHHCCHHHH	33.10	27667366
111	Phosphorylation	RTSNGKSTVINAMLW ECCCCCCCEEEHHHC	28.97	-
177	Phosphorylation	DEQLHAGSMVSVMWP CCCCCCCCEEEEECC	19.45	22871156
186	Phosphorylation	VSVMWPNSKCPLLKD EEEECCCCCCCCCCC	31.39	22871156
249	Phosphorylation	HKVSERLSRPNIFIL HHHHHHHCCCCEEEE	52.49	23140645
442	Phosphorylation	AEEIRRLSVLVDEYQ HHHHHHHHHHHHHHC	16.16	22817900
448	Phosphorylation	LSVLVDEYQMDFHPS HHHHHHHHCCCCCCC	12.50	22817900
609	Phosphorylation	SMVTGLASLTSRTSM HHHHHHHHHCCCCCC	36.90	27180971
611	Phosphorylation	VTGLASLTSRTSMGI HHHHHHHCCCCCCEE	17.42	29472430
657	Sumoylation	LTWTTKAKERAFKRQ HHCCHHHHHHHHHHH	49.65	28289178
719	Methylation	QEIAAMNKKVEALDS HHHHHHHHHHHHHHH	45.15	-
720	Ubiquitination	EIAAMNKKVEALDSL HHHHHHHHHHHHHHH	40.06	-
726	Phosphorylation	KKVEALDSLQSRAKL HHHHHHHHHHHHHHH	29.20	-
756	Phosphorylation	THQYLQPSR------ HHHHCCCCC------	37.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
111	T	Phosphorylation	Kinase	PINK1	Q99MQ3	Uniprot
442	S	Phosphorylation	Kinase	PINK1	Q99MQ3	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFN2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MFN1_MOUSE	Mfn1	physical	12527753
PRKN_HUMAN	PARK2	physical	23620051
PRKN_MOUSE	Park2	physical	23620051

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.