PCH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCH2_MOUSE
• UniProt AC: Q3UA06
• Protein Name: Pachytene checkpoint protein 2 homolog
• Gene Name: Trip13
• Organism: Mus musculus (Mouse).
• Sequence Length: 432
• Protein Description: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. [PubMed: 17696610]
• Protein Sequence: MDEAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDEAVGDL -------CCCHHHHH	10.69	-
152	Phosphorylation	VKSHLLDYVMTTVLF HHHHHHHHHHHHHHC	7.65	25162660
155	Phosphorylation	HLLDYVMTTVLFSDK HHHHHHHHHHHCCCC	12.05	25162660
156	Phosphorylation	LLDYVMTTVLFSDKN HHHHHHHHHHCCCCC	9.34	25162660
201	Phosphorylation	QKLTIRLSSRYRYGQ HHHHHEHHHCCCCCE	11.70	23140645
202	Phosphorylation	KLTIRLSSRYRYGQL HHHHEHHHCCCCCEE	37.61	23140645
302	Phosphorylation	ILTTSNITEKIDVAF EEECCCCCCEECEEE	35.16	-
318	Phosphorylation	DRADIKQYIGPPSAA CHHHHHHHHCCHHHH	11.66	24759943
323	Phosphorylation	KQYIGPPSAAAIFKI HHHHCCHHHHHHHHH	33.40	24759943

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCH2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCH2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD4_MOUSE	Chd4	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.