MEIOC_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEIOC_MOUSE
• UniProt AC: A2AG06
• Protein Name: Meiosis-specific coiled-coil domain-containing protein MEIOC {ECO:0000305}
• Gene Name: Meioc {ECO:0000312|MGI:MGI:2686410}
• Organism: Mus musculus (Mouse).
• Sequence Length: 965
• Subcellular Localization: Cytoplasm . Nucleus . at late pachytene a fraction is nuclear.
• Protein Description: Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle. [PubMed: 28380054]
• Protein Sequence: MEVSGGDTCRPRHPQGLREGPEPKVAAAAAAFRGSANRCWNLSVDTSNRLSDVFNSMMLTGSAPFYDCYKSQNEDNVDLRQTCTPLSSSTEYASSIDSSLFYAPWSTYGDDIKQPPSSQISVKNRIQTERNDYGSETDLYGLVSNILEEQDKSQPYFAEGTCSSNLKSVWPMNTSRFVDHHDLLTEPKRPVDTSISQQAFYSGESVSAVEKQYLHNSSLTPQQKIDELYHGYTGLDLEEQWLYLSRSDHSNCYNSQANDTVKATFQEYPFVKNCFTPQTGLSDIMKESGIDTYAYGREKICTKGLETPLQHKRAEIFLSQFNRYNENADYCRYPEYAHPNKAKLNKCSNFSVQDGKKLANGTPETPTVEADAYTKLFQVKPANQKKMEETIPDQQNFAFPKTTPHLTEKQFAKEAAFTADFGLKSEYGLKPHTACPTNNDFANVSEKQQFAKPDPLNSEYFKSVNLFSNSATSSGGISLNRPTWMNVQTKNNLPIPYRNQGNLMKLNSHLSAASKGSNHSSDFPQLSSTNLTSNSNLFQKYCQENPSAFSSFDFSYNGAERIQSVNHMEGLTKTGEDNLFESVTEKKIKQPNGFCDSYSASQYGIIENVNKHNFQAKPQSGHYDPEDIPKHFDGLPQNTYQDLLESQGHFNSHRQGSGDNNINSRVNRTQASCFSNNYMMGDLRHNQGFQQLGSNGFPLRSTHPFGHSVVPLLDSYDLFSYDDLSHLYPYFNDMMYGDNSFSGFVPTFGFQRPIKTRSGPASELHIRLEECYEQWRALEKERKKTELALAKNYPGKKVSSTNNTPIPRLTSNPSRVDRLIVDELREQARVVTLLGKMERLRSSPLHANISTALDRHLESIHIVQSRRKDEIVNASNRQRQGVPRCQDDRDVFALATAIKEMCVATRKARTTLWCALQMTLPKTASTAGQADMEKAFQDLVNCEEKVHESINSSNPMNQRGETSKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MEVSGGDTCRPRHPQ CCCCCCCCCCCCCCC		28059163
35	Phosphorylation	AAAAFRGSANRCWNL HHHHHHCCCHHEEEC		25619855
117	Phosphorylation	DDIKQPPSSQISVKN CCCCCCCHHHCEEEC		25777480
118	Phosphorylation	DIKQPPSSQISVKNR CCCCCCHHHCEEECC		25777480
121	Phosphorylation	QPPSSQISVKNRIQT CCCHHHCEEECCCCC		25777480
133	Phosphorylation	IQTERNDYGSETDLY CCCCCCCCCCHHHHH		25293948
135	Phosphorylation	TERNDYGSETDLYGL CCCCCCCCHHHHHHH		25293948
137	Phosphorylation	RNDYGSETDLYGLVS CCCCCCHHHHHHHHH		25293948
140	Phosphorylation	YGSETDLYGLVSNIL CCCHHHHHHHHHHHH		25293948
800	Phosphorylation	YPGKKVSSTNNTPIP CCCCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEIOC_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEIOC_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEIOC_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MEIOC_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.