NMNA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NMNA1_MOUSE
• UniProt AC: Q9EPA7
• Protein Name: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 {ECO:0000305}
• Gene Name: Nmnat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 285
• Subcellular Localization: Nucleus .
• Protein Description: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. [PubMed: 15381699 Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity Can use triazofurin monophosphate (TrMP) as substrate (By similarity Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity Protects against axonal degeneration following mechanical or toxic insults]
• Protein Sequence: MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	DYMHATGKYSVIKGI HHHHHHCCCHHHHEE	29.96	22902405
116	Phosphorylation	GSCSYPQSSPALEKP CCCCCCCCCCCCCCC	33.51	26643407
117	Phosphorylation	SCSYPQSSPALEKPG CCCCCCCCCCCCCCC	14.67	26643407
136	Phosphorylation	WADQKQDSSPQKPQE CCCCCCCCCCCCCCC	41.23	25159016
137	Phosphorylation	ADQKQDSSPQKPQEP CCCCCCCCCCCCCCC	39.37	23684622
147	Phosphorylation	KPQEPKPTGVPKVKL CCCCCCCCCCCCEEE	57.87	18846507
251	Acetylation	LVQEYIEKHELYNTE HHHHHHHHCCCCCCC	32.59	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NMNA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NMNA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NMNA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NMNA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.