HSPB8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSPB8_MOUSE
• UniProt AC: Q9JK92
• Protein Name: Heat shock protein beta-8
• Gene Name: Hspb8
• Organism: Mus musculus (Mouse).
• Sequence Length: 196
• Subcellular Localization: Cytoplasm . Nucleus . Translocates to nuclear foci during heat shock.
• Protein Description: Displays temperature-dependent chaperone activity..
• Protein Sequence: MADGQLPFPCSYPSRLRRDPFRDSPLSSRLLDDGFGMDPFPDDLTAPWPEWALPRLSSAWPGTLRSGMVPRGPPATARFGVPAEGRSPPPFPGEPWKVCVNVHSFKPEELMVKTKDGYVEVSGKHEEKQQEGGIVSKNFTKKIQLPAEVDPATVFASLSPEGLLIIEAPQVPPYSPFGESSFNNELPQDNQEVTCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GQLPFPCSYPSRLRR CCCCCCCCCCCHHCC	40.07	28066266
12	Phosphorylation	QLPFPCSYPSRLRRD CCCCCCCCCCHHCCC	16.37	28066266
14	Phosphorylation	PFPCSYPSRLRRDPF CCCCCCCCHHCCCCC	35.40	28066266
24	Phosphorylation	RRDPFRDSPLSSRLL CCCCCCCCCCHHHHC	24.39	26824392
27	Phosphorylation	PFRDSPLSSRLLDDG CCCCCCCHHHHCCCC	19.45	23737553
28	Phosphorylation	FRDSPLSSRLLDDGF CCCCCCHHHHCCCCC	34.33	29472430
57	Phosphorylation	EWALPRLSSAWPGTL HHHCHHHHHCCCCCC	21.20	21454597
58	Phosphorylation	WALPRLSSAWPGTLR HHCHHHHHCCCCCCC	38.66	28066266
63	Phosphorylation	LSSAWPGTLRSGMVP HHHCCCCCCCCCCCC	18.21	28066266
65	Methylation	SAWPGTLRSGMVPRG HCCCCCCCCCCCCCC	30.88	58857939
71	Methylation	LRSGMVPRGPPATAR CCCCCCCCCCCCCHH	59.86	24129315
71	Asymmetric dimethylarginine	LRSGMVPRGPPATAR CCCCCCCCCCCCCHH	59.86	-
76	Phosphorylation	VPRGPPATARFGVPA CCCCCCCCHHCCCCC	24.92	21454597
78	Asymmetric dimethylarginine	RGPPATARFGVPAEG CCCCCCHHCCCCCCC	25.21	-
78	Methylation	RGPPATARFGVPAEG CCCCCCHHCCCCCCC	25.21	24129315
87	Phosphorylation	GVPAEGRSPPPFPGE CCCCCCCCCCCCCCC	53.25	24925903
128	Ubiquitination	VSGKHEEKQQEGGIV ECCCCCHHHCCCCEE	55.06	-
140	Phosphorylation	GIVSKNFTKKIQLPA CEECCCCCCCCCCCC	40.60	21454597
181	Phosphorylation	YSPFGESSFNNELPQ CCCCCCCCCCCCCCC	27.91	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSPB8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSPB8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSPB8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HSPB8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND MASSSPECTROMETRY.
PubMed: 19131326