SDHB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SDHB_MOUSE
• UniProt AC: Q9CQA3
• Protein Name: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
• Gene Name: Sdhb
• Organism: Mus musculus (Mouse).
• Sequence Length: 282
• Subcellular Localization: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
• Protein Description: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)..
• Protein Sequence: MAATVGVSLKRGFPAAVLGRVGLQFQACRGAQTAAAAAPRIKKFAIYRWDPDKTGDKPRMQTYEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTDLSKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEDREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSVYRCHTIMNCTQTCPKGLNPGKAIAEIKKMMATYKEKRALA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Acetylation	AAAPRIKKFAIYRWD HHCCHHCEEEEEECC		24062335
53	Acetylation	IYRWDPDKTGDKPRM EEECCCCCCCCCCCC		23576753
57	Acetylation	DPDKTGDKPRMQTYE CCCCCCCCCCCEEEE		23576753
62	Phosphorylation	GDKPRMQTYEVDLNK CCCCCCEEEEECHHH		28576409
69	Acetylation	TYEVDLNKCGPMVLD EEEECHHHHHHHHHH		24062335
69	Succinylation	TYEVDLNKCGPMVLD EEEECHHHHHHHHHH		26388266
70	S-nitrosocysteine	YEVDLNKCGPMVLDA EEECHHHHHHHHHHH		-
70	S-palmitoylation	YEVDLNKCGPMVLDA EEECHHHHHHHHHHH		28526873
125	Acetylation	RIDTDLSKVSKIYPL ECCCCHHHHCCEECC		23201123
128	Acetylation	TDLSKVSKIYPLPHM CCHHHHCCEECCCCE		24062335
128	Succinylation	TDLSKVSKIYPLPHM CCHHHHCCEECCCCE		23954790
139	Acetylation	LPHMYVIKDLVPDLS CCCEEEHHHHCCCHH		23864654
146	Phosphorylation	KDLVPDLSNFYAQYK HHHCCCHHHHHHHHH		23984901
149	Phosphorylation	VPDLSNFYAQYKSIE CCCHHHHHHHHHCCH		23984901
152	Phosphorylation	LSNFYAQYKSIEPYL HHHHHHHHHCCHHHH		23984901
153	Acetylation	SNFYAQYKSIEPYLK HHHHHHHHCCHHHHC		23954790
153	Succinylation	SNFYAQYKSIEPYLK HHHHHHHHCCHHHHC		23954790
160	Acetylation	KSIEPYLKKKDESQE HCCHHHHCCCCCCHH		23864654
160	Succinylation	KSIEPYLKKKDESQE HCCHHHHCCCCCCHH		23954790
169	Acetylation	KDESQEGKQQYLQSI CCCCHHHHHHHHHHH		23864654
208	Phosphorylation	YWWNGDKYLGPAVLM CCCCCCCCCHHHHHH		22817900
218	Phosphorylation	PAVLMQAYRWMIDSR HHHHHHHHHHHHHCC		22817900
224	Phosphorylation	AYRWMIDSRDDFTEE HHHHHHHCCCCCCHH		22817900
235	Ubiquitination	FTEERLAKLQDPFSV CCHHHHHHCCCCCCE		-
235	Acetylation	FTEERLAKLQDPFSV CCHHHHHHCCCCCCE		23576753
251	S-palmitoylation	RCHTIMNCTQTCPKG EEECCCCCCCCCCCC		28526873
255	S-palmitoylation	IMNCTQTCPKGLNPG CCCCCCCCCCCCCCH		28526873
269	Acetylation	GKAIAEIKKMMATYK HHHHHHHHHHHHHHH		23576753
276	Succinylation	KKMMATYKEKRALA- HHHHHHHHHHHHHC-		23806337
276	Acetylation	KKMMATYKEKRALA- HHHHHHHHHHHHHC-		23806337
278	Acetylation	MMATYKEKRALA--- HHHHHHHHHHHC---		6566475

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SDHB_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SDHB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SDHB_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SDHB_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.