TLR9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLR9_MOUSE
• UniProt AC: Q9EQU3
• Protein Name: Toll-like receptor 9
• Gene Name: Tlr9
• Organism: Mus musculus (Mouse).
• Sequence Length: 1032
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endosome . Lysosome . Cytoplasmic vesicle, phagosome . Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (PubMed:18305481). Exit from t
• Protein Description: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. [PubMed: 18931679]
• Protein Sequence: MVLRRRTLHPLSLLVQAAVLAETLALGTLPAFLPCELKPHGLVDCNWLFLKSVPRFSAAASCSNITRLSLISNRIHHLHNSDFVHLSNLRQLNLKWNCPPTGLSPLHFSCHMTIEPRTFLAMRTLEELNLSYNGITTVPRLPSSLVNLSLSHTNILVLDANSLAGLYSLRVLFMDGNCYYKNPCTGAVKVTPGALLGLSNLTHLSLKYNNLTKVPRQLPPSLEYLLVSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDHAPNPCIECGQKSLHLHPETFHHLSHLEGLVLKDSSLHTLNSSWFQGLVNLSVLDLSENFLYESITHTNAFQNLTRLRKLNLSFNYRKKVSFARLHLASSFKNLVSLQELNMNGIFFRLLNKYTLRWLADLPKLHTLHLQMNFINQAQLSIFGTFRALRFVDLSDNRISGPSTLSEATPEEADDAEQEELLSADPHPAPLSTPASKNFMDRCKNFKFTMDLSRNNLVTIKPEMFVNLSRLQCLSLSHNSIAQAVNGSQFLPLTNLQVLDLSHNKLDLYHWKSFSELPQLQALDLSYNSQPFSMKGIGHNFSFVTHLSMLQSLSLAHNDIHTRVSSHLNSNSVRFLDFSGNGMGRMWDEGGLYLHFFQGLSGLLKLDLSQNNLHILRPQNLDNLPKSLKLLSLRDNYLSFFNWTSLSFLPNLEVLDLAGNQLKALTNGTLPNGTLLQKLDVSSNSIVSVVPAFFALAVELKEVNLSHNILKTVDRSWFGPIVMNLTVLDVRSNPLHCACGAAFVDLLLEVQTKVPGLANGVKCGSPGQLQGRSIFAQDLRLCLDEVLSWDCFGLSLLAVAVGMVVPILHHLCGWDVWYCFHLCLAWLPLLARSRRSAQTLPYDAFVVFDKAQSAVADWVYNELRVRLEERRGRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVLAHTDRVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRLRQRLCRQSVLFWPQQPNGQGGFWAQLSTALTRDNRHFYNQNFCRGPTAE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	N-linked_Glycosylation	SAAASCSNITRLSLI CHHHHCCCCHHHHHH	43.93	-
129	N-linked_Glycosylation	MRTLEELNLSYNGIT HHHHHHHCCCCCCCC	30.16	-
147	N-linked_Glycosylation	RLPSSLVNLSLSHTN CCCHHHHEECCCCCC	29.25	-
200	N-linked_Glycosylation	GALLGLSNLTHLSLK CCCCCCHHCCHHHHH	54.74	-
210	N-linked_Glycosylation	HLSLKYNNLTKVPRQ HHHHHCCCCCCCCCC	46.10	25686612
242	N-linked_Glycosylation	LGPEDLANLTSLRVL CCHHHHCCCCEEEEE	51.66	-
300	N-linked_Glycosylation	DSSLHTLNSSWFQGL CCCCCCCCCHHHHHC	34.84	-
309	N-linked_Glycosylation	SWFQGLVNLSVLDLS HHHHHCCCCHHHCCC	31.47	-
332	N-linked_Glycosylation	THTNAFQNLTRLRKL CCCCHHHHHHHHHHC	36.61	25686612
340	N-linked_Glycosylation	LTRLRKLNLSFNYRK HHHHHHCCCCCCHHH	36.35	-
495	N-linked_Glycosylation	IKPEMFVNLSRLQCL ECHHHEECHHHHHHH	22.49	-
514	N-linked_Glycosylation	NSIAQAVNGSQFLPL CHHHHHHCCCCCCCC	47.62	-
568	N-linked_Glycosylation	SMKGIGHNFSFVTHL CCCCCCCCHHHHHHH	29.10	-
655	Phosphorylation	NLDNLPKSLKLLSLR CCCCCCHHHHHHHCC	28.88	-
670	N-linked_Glycosylation	DNYLSFFNWTSLSFL CCCHHHCCCCCHHHC	38.82	-
695	N-linked_Glycosylation	NQLKALTNGTLPNGT HHHHHHHCCCCCCCC	42.15	-
700	N-linked_Glycosylation	LTNGTLPNGTLLQKL HHCCCCCCCCEEEEE	60.23	-
732	N-linked_Glycosylation	AVELKEVNLSHNILK HHHHHHCCCCCCHHH	36.60	25686612
752	N-linked_Glycosylation	WFGPIVMNLTVLDVR HCCCEEEEEEEEECC	22.97	-
861	Phosphorylation	WLPLLARSRRSAQTL HHHHHHHCCCCCCCC	26.83	23882026

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TLR9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLR9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLR9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TLR9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.