RAB5B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB5B_MOUSE
• UniProt AC: P61021
• Protein Name: Ras-related protein Rab-5B
• Gene Name: Rab5b
• Organism: Mus musculus (Mouse).
• Sequence Length: 215
• Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome.
• Protein Description: Protein transport. Probably involved in vesicular traffic (By similarity)..
• Protein Sequence: MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSRSTARP ------CCCCCCCCC	32.61	-
29	Phosphorylation	KLVLLGESAVGKSSL EEEEECCCCCCCCHH	26.84	22817900
33	Ubiquitination	LGESAVGKSSLVLRF ECCCCCCCCHHHHHH	30.21	-
34	Phosphorylation	GESAVGKSSLVLRFV CCCCCCCCHHHHHHH	23.99	23737553
35	Phosphorylation	ESAVGKSSLVLRFVK CCCCCCCHHHHHHHC	26.44	23737553
82	Phosphorylation	DTAGQERYHSLAPMY ECCCCCCCHHHCCCH	8.60	25367039
84	Phosphorylation	AGQERYHSLAPMYYR CCCCCCHHHCCCHHC	19.79	25367039
89	Phosphorylation	YHSLAPMYYRGAQAA CHHHCCCHHCCCCEE	6.75	29514104
116	Ubiquitination	ARAKTWVKELQRQAS HHHHHHHHHHHHHCC	44.24	-
123	Phosphorylation	KELQRQASPSIVIAL HHHHHHCCCCEEEEE	15.73	25521595
125	Phosphorylation	LQRQASPSIVIALAG HHHHCCCCEEEEECC	27.30	25195567
134	Ubiquitination	VIALAGNKADLANKR EEEECCCHHHHCHHH	42.22	-
140	Ubiquitination	NKADLANKRMVEYEE CHHHHCHHHHCCHHH	35.94	-
183	Acetylation	AIAKKLPKSEPQNLG HHHHHCCCCCCCCCC	77.28	23201123
212	Geranylgeranylation	SQQNKSQCCSN---- HHHHHHHHCCC----	3.38	-
213	Geranylgeranylation	QQNKSQCCSN----- HHHHHHHCCC-----	3.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB5B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
84	S	Phosphorylation	Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB5B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRRK2_MOUSE	Lrrk2	physical	18445495
LRRK2_MOUSE	Lrrk2	genetic	18445495
CDC27_HUMAN	CDC27	physical	26496610
RAB5C_HUMAN	RAB5C	physical	26496610
XPO1_HUMAN	XPO1	physical	26496610
KCAB2_HUMAN	KCNAB2	physical	26496610
SPTC1_HUMAN	SPTLC1	physical	26496610
UH1BL_HUMAN	UHRF1BP1L	physical	26496610
LTMD1_HUMAN	LETMD1	physical	26496610
EIF3L_HUMAN	EIF3L	physical	26496610
ASXL2_HUMAN	ASXL2	physical	26496610
AFAP1_HUMAN	AFAP1	physical	26496610
RN123_HUMAN	RNF123	physical	26496610
CLSPN_HUMAN	CLSPN	physical	26496610
DEPD7_HUMAN	DEPDC7	physical	26496610
OSBL1_HUMAN	OSBPL1A	physical	26496610
TM201_HUMAN	TMEM201	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.