MTPN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTPN_MOUSE
• UniProt AC: P62774
• Protein Name: Myotrophin
• Gene Name: Mtpn
• Organism: Mus musculus (Mouse).
• Sequence Length: 118
• Subcellular Localization: Cytoplasm . Nucleus. Cytoplasm, perinuclear region.
• Protein Description: Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex formed by the CAPZA1 and CAPZB heterodimer..
• Protein Sequence: MCDKEFMWALKNGDLDEVKDYVAKGEDVNRTLEGGRKPLHYAADCGQLEILEFLLLKGADINAPDKHHITPLLSAVYEGHVSCVKLLLSKGADKTVKGPDGLTALEATDNQAIKALLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MCDKEFMWA ------CCCHHHHHH	11.71	23806337
4	Acetylation	----MCDKEFMWALK ----CCCHHHHHHHH	48.18	23806337
4	Ubiquitination	----MCDKEFMWALK ----CCCHHHHHHHH	48.18	22790023
11	Acetylation	KEFMWALKNGDLDEV HHHHHHHHCCCHHHH	51.65	23236377
19	Acetylation	NGDLDEVKDYVAKGE CCCHHHHHHHHHCCC	41.09	23236377
24	Acetylation	EVKDYVAKGEDVNRT HHHHHHHCCCCCCCH	53.43	21728379
24	Ubiquitination	EVKDYVAKGEDVNRT HHHHHHHCCCCCCCH	53.43	27667366
31	Phosphorylation	KGEDVNRTLEGGRKP CCCCCCCHHCCCCCC	24.77	26824392
41	Phosphorylation	GGRKPLHYAADCGQL CCCCCCEEECCCCHH	15.92	26060331
82	Phosphorylation	AVYEGHVSCVKLLLS HHHHCCHHHHHHHHH	13.91	-
97	Ubiquitination	KGADKTVKGPDGLTA CCCCCCEECCCCCCH	70.70	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTPN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTPN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTPN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MTPN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.