| UniProt ID | DPM1_MOUSE | |
|---|---|---|
| UniProt AC | O70152 | |
| Protein Name | Dolichol-phosphate mannosyltransferase subunit 1 | |
| Gene Name | Dpm1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 260 | |
| Subcellular Localization | Endoplasmic reticulum. | |
| Protein Description | Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.. | |
| Protein Sequence | MASTGASRSLAASPRPPQGRSSRQDKYSVLLPTYNERENLPLIVWLLVKSFSESAINYEIIIIDDGSPDGTREVAEQLAEIYGPDRILLRPREKKLGLGTAYIHGIKHATGNYVIIMDADLSHHPKFIPEFIRKQKEGNFDIVSGTRYKGNGGVYGWDLKRKIISRGANFITQILLRPGASDLTGSFRLYRKEVLQKLIEKCVSKGYVFQMEMIVRARQMNYTIGEVPISFVDRVYGESKLGGNEIVSFLKGLLTLFATT | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASTGASRS ------CCCCCCCCC | 18.79 | - | |
| 3 | Phosphorylation | -----MASTGASRSL -----CCCCCCCCCC | 26.52 | - | |
| 4 | Phosphorylation | ----MASTGASRSLA ----CCCCCCCCCCC | 27.51 | 28576409 | |
| 9 | Phosphorylation | ASTGASRSLAASPRP CCCCCCCCCCCCCCC | 21.62 | 23984901 | |
| 13 | Phosphorylation | ASRSLAASPRPPQGR CCCCCCCCCCCCCCC | 18.81 | 28507225 | |
| 82 | Phosphorylation | AEQLAEIYGPDRILL HHHHHHHHCCCCEEE | 17.70 | 20469934 | |
| 100 | Phosphorylation | EKKLGLGTAYIHGIK HHCCCCCHHHHCCCE | 22.72 | 25619855 | |
| 102 | Phosphorylation | KLGLGTAYIHGIKHA CCCCCHHHHCCCEEC | 8.03 | 25619855 | |
| 113 | Phosphorylation | IKHATGNYVIIMDAD CEECCCCEEEEEECC | 8.38 | - | |
| 217 | Ubiquitination | QMEMIVRARQMNYTI EHHHHHHHHHCCCEE | 8.65 | 27667366 | |
| 222 | Phosphorylation | VRARQMNYTIGEVPI HHHHHCCCEECCCCE | 8.39 | 20415495 | |
| 223 | Phosphorylation | RARQMNYTIGEVPIS HHHHCCCEECCCCEE | 19.94 | 20415495 | |
| 230 | Phosphorylation | TIGEVPISFVDRVYG EECCCCEEHHHHHHC | 17.10 | 22817900 | |
| 236 | Phosphorylation | ISFVDRVYGESKLGG EEHHHHHHCCCCCCH | 18.97 | 20415495 | |
| 240 | Ubiquitination | DRVYGESKLGGNEIV HHHHCCCCCCHHHHH | 47.01 | 27667366 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DPM1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DPM1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DPM1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of DPM1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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