PLCA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLCA_MOUSE
• UniProt AC: O35083
• Protein Name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
• Gene Name: Agpat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 285
• Subcellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone..
• Protein Sequence: MELWPGAWTALLLLLLLLLSTLWFCSSSAKYFFKMAFYNGWILFLAILAIPVCAVRGRNVENMKILRLLLLHAKYLYGIRVEVRGAHHFPPTQPYVVVSNHQSSLDLLGMMEVLPDRCVPIAKRELLWAGSAGLACWLAGIIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIIPIVMSSYQDFYSKKERRFTSPGRCQVRVLPPVSTEGLTPDDVPALADSVRHSMLTIFREISTDGLGGGDCLKKPGGAGEARL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
264	Phosphorylation	LTIFREISTDGLGGG HHHHHHHCCCCCCCC	18.72	30635358
265	Phosphorylation	TIFREISTDGLGGGD HHHHHHCCCCCCCCC	39.48	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLCA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLCA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLCA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PLCA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.