DDAH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDAH2_MOUSE
• UniProt AC: Q99LD8
• Protein Name: N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
• Gene Name: Ddah2
• Organism: Mus musculus (Mouse).
• Sequence Length: 285
• Subcellular Localization: Cytoplasm. Mitochondrion. Translocates from cytosol to mitochondrion upon IL-1beta stimulation in chondrocytes..
• Protein Description: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity)..
• Protein Sequence: MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MGTPGEGLGR -----CCCCCCCCCH	27.16	20415495
40	Acetylation	LPALDLAKAQREHGV CCHHHHHHHHHHHCC	52.96	15629527
105	Ubiquitination	PEVDGVRKALQDLGL CCCCHHHHHHHHHCC	51.55	22790023
194	Ubiquitination	GSSEAAQKAVRAMAA CCHHHHHHHHHHHHH	44.09	22790023
261	O-linked_Glycosylation	DVTLVPVSCSELEKA CCEEEECCHHHHHHC	13.07	72838389
262	S-nitrosocysteine	VTLVPVSCSELEKAG CEEEECCHHHHHHCC	3.59	-
262	S-nitrosylation	VTLVPVSCSELEKAG CEEEECCHHHHHHCC	3.59	21278135
267	Acetylation	VSCSELEKAGAGLSS CCHHHHHHCCCCHHH	65.82	22826441

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDAH2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDAH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDAH2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DDAH2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.