SPTC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPTC3_MOUSE
• UniProt AC: Q8BG54
• Protein Name: Serine palmitoyltransferase 3
• Gene Name: Sptlc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 563
• Subcellular Localization: Endoplasmic reticulum membrane; Single-pass membrane protein.
• Protein Description: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference (By similarity)..
• Protein Sequence: MANLNDSAVTNGTLHNPKTQQGKRQSTGCVKNGISKEAQQNRKAYAEDKPVFEPYQEAPLYVYVLTYMGYGIGILFGYLRDFMRNWGIEKCNAAVEREEQKDFVPLYQDFENFYKRNLYMRIRDSWSHTVCSAPEPYMNVMEKVTDDYNWTFRHTGKVIENIINMASYNYLGLAGKYDDSMVRVKDTLEKYGVGVASTRNEMGTLDIHKELEDLMAEFLNVEAVMSFGMGFATNAMNIPVFVGKGCLILSDEFNHTSVILGSRLSGAVIRPFKHNNAENLEKLLREAIIRGQPGTGRAWKKILIVVEGVYSMEGSIVNLAQIVALKKKYKAYLYIDEAHSIGCTGPTGRGVRELFGLDPEDIDVYMGTFTKSFSGSGGYIGGKKEIVDYLRMQSHSTTYATSMSPVVAAQLIRSLKITMGYEGNIGGMERIQQLKENIKYFRRRLKEMGFIIYGNDFSPVIPVLLYMPAKVSAFSRFLLKKKISVVVVGFPATSLPEGRARFSMSSAHTREMLDTVLEVVDELGDLLNVKYFPLKKSGRAILYNKEGFDNEASFEEMHSEPEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Phosphorylation	TQQGKRQSTGCVKNG CCCCCCCCCCCHHCC	30.69	23375375
371	N6-(pyridoxal phosphate)lysine	VYMGTFTKSFSGSGG EEEEECCCCCCCCCC	45.36	-
371	Other	VYMGTFTKSFSGSGG EEEEECCCCCCCCCC	45.36	-
515	Phosphorylation	HTREMLDTVLEVVDE HHHHHHHHHHHHHHH	24.03	25777480
531	Phosphorylation	GDLLNVKYFPLKKSG HHHCCCEEEECCCCC	13.22	25777480
553	Phosphorylation	EGFDNEASFEEMHSE CCCCCCCCHHHHHCC	27.32	23375375
559	Phosphorylation	ASFEEMHSEPEA--- CCHHHHHCCCCC---	54.24	23375375

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPTC3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPTC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPTC3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPTC3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.