EPB42_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPB42_MOUSE
• UniProt AC: P49222
• Protein Name: Erythrocyte membrane protein band 4.2
• Gene Name: Epb42
• Organism: Mus musculus (Mouse).
• Sequence Length: 691
• Subcellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasmic surface of erythrocyte membranes.
• Protein Description: Probably plays an important role in the regulation of erythrocyte shape and mechanical properties..
• Protein Sequence: MGQALSIKSCDFHAAENNEEHYTKAISSQHLTLRRGQSFTITLNFRAPTHTFLSALKKVALIAQTGEQPSKINKTQAIFPISSLGDQKGWSAAVEERDAQHWTVSVTTPVDAVIGHYSLLLQVSGKKQYPLGQFTLLFNPWNRDDAVFLQNEAERTEYVLNQNGFIYLGTADCIQEEPWDFGQFEKDVMDLSLKLLSMDKQVKDWNQPAHVARVVGALLHALKKKSVLPISQTQAAQEGALLYKRRGSVPILRQWLTGQGRAVYETQAWVSAAVACTVLRCLGIPARVVTTFDSAQGTVGSLLVDEYYNEEGLQNGEGQRGHIWVFQTSVECWMNRPDLSQGYGGWQILHPRAPNGAGVLGSCSLVPVRAVKEGELQLDPAVPELFAAVNASCVVWKCCEDGKLELTNSNRKDVGNCISTKVVGSDRCEDITQNYKYPAGSLQEKEVLEKVQKERLKLGKDNGMCPPSCEPWDPLHMFFEASSSIPLSGDGQLSVTLINPTDEEKKVHLVIGAQALYYNGVLAAGLWSKKQLFMLKPNQVMRLSTNLSFSCFEQTPPENSFLRVTAMARYSHTSLSCFAQENMAIGKPDLIIEMPKRAAQYRPLTVSVRMHNSLEAPMQNCIISIFGRGLIHREKRYGLGSLWPGSSLHTQFQFTPTHLGLQRLTVEVDCDMFQNLTGYRSVLVVAPEVSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGQALSIKS ------CCCCCEEEC	22.82	-
49	Phosphorylation	TLNFRAPTHTFLSAL EEEEECCCHHHHHHH	32.34	28576409
51	Phosphorylation	NFRAPTHTFLSALKK EEECCCHHHHHHHHH	28.84	28576409
200	Ubiquitination	LKLLSMDKQVKDWNQ HHHHCCCHHCCCCCC	48.64	22790023
223	Ubiquitination	GALLHALKKKSVLPI HHHHHHHHHCCCCCC	59.96	22790023
225	Ubiquitination	LLHALKKKSVLPISQ HHHHHHHCCCCCCCH	44.18	22790023
226	Phosphorylation	LHALKKKSVLPISQT HHHHHHCCCCCCCHH	37.45	-
243	Phosphorylation	AQEGALLYKRRGSVP HHHCCCCEEECCCCC	11.87	-
248	Phosphorylation	LLYKRRGSVPILRQW CCEEECCCCCEEEHH	23.94	22817900
403	Ubiquitination	WKCCEDGKLELTNSN EEECCCCCEEECCCC	51.62	-
544	Phosphorylation	PNQVMRLSTNLSFSC HHHEEEEECCCEEEC	12.60	21454597
545	Phosphorylation	NQVMRLSTNLSFSCF HHEEEEECCCEEECC	44.78	21454597
548	Phosphorylation	MRLSTNLSFSCFEQT EEEECCCEEECCCCC	19.72	21454597
550	Phosphorylation	LSTNLSFSCFEQTPP EECCCEEECCCCCCC	17.96	21454597
555	Phosphorylation	SFSCFEQTPPENSFL EEECCCCCCCCCCCC	33.34	21454597
570	Phosphorylation	RVTAMARYSHTSLSC HHEEEEECCCCHHHH	8.68	22817900
571	Phosphorylation	VTAMARYSHTSLSCF HEEEEECCCCHHHHH	18.09	21082442
573	Phosphorylation	AMARYSHTSLSCFAQ EEEECCCCHHHHHHH	25.98	21082442
574	Phosphorylation	MARYSHTSLSCFAQE EEECCCCHHHHHHHC	16.92	21082442
576	Phosphorylation	RYSHTSLSCFAQENM ECCCCHHHHHHHCCC	13.62	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPB42_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPB42_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPB42_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EPB42_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.