CLPX_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLPX_MOUSE
• UniProt AC: Q9JHS4
• Protein Name: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial
• Gene Name: Clpx
• Organism: Mus musculus (Mouse).
• Sequence Length: 634
• Subcellular Localization: Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid.
• Protein Description: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. [PubMed: 10347188 ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. Important for efficient erythropoiesis through upregulation of heme biosynthesis (By similarity]
• Protein Sequence: MSSCGACTCGAAAARLLTTSLTSAQRGISCGRIHVPVLGRLGTTLDAQALRRAPLRTFSETPAYFASKDGANKDGSGDGNKKSVTEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEAEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQMPQEKRGGEVLDSSQDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNVLFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPSKESSEEEYDSGVEEDGWPRQADAANS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
76	Phosphorylation	DGANKDGSGDGNKKS CCCCCCCCCCCCCCC	43.79	22871156
92	Phosphorylation	TEGSSKKSGSGNSGK CCCCCCCCCCCCCCC	41.76	-
94	Phosphorylation	GSSKKSGSGNSGKGG CCCCCCCCCCCCCCC	41.72	-
97	Phosphorylation	KKSGSGNSGKGGNQL CCCCCCCCCCCCCCE	45.46	-
127	Acetylation	VSSTRFVKCEKCHHF HHCCCEEECCCCCEE	33.68	-
149	Acetylation	DSKKSIIKEPESAAE HHCCCCCCCHHHHHH	66.60	-
174	Phosphorylation	PPPPKKIYNYLDKYV CCCCHHHHHHHHHHH	13.46	-
176	Phosphorylation	PPKKIYNYLDKYVVG CCHHHHHHHHHHHHC	10.17	-
180	Phosphorylation	IYNYLDKYVVGQSFA HHHHHHHHHHCHHHH	10.47	-
279	Phosphorylation	GGEVLDSSQDDIKLE CCCCCCCCCCCCEEC	36.98	-
438	Acetylation	ISRRKNEKYLGFGTP HHHCCCCCCCCCCCC	55.99	-
444	Phosphorylation	EKYLGFGTPSNLGKG CCCCCCCCCCCCCCH	22.68	22006019
476	Acetylation	THQDIEEKDRLLRHV CCCCHHHHHHHHHHH	35.04	66699541
530	Phosphorylation	RNAVIPQYQALFSMD CCCCCHHHHHHHCCC	7.15	22802335
608	Phosphorylation	PGYIRAPSKESSEEE CCCCCCCCCCCCHHH	48.33	25293948
611	Phosphorylation	IRAPSKESSEEEYDS CCCCCCCCCHHHHHC	46.95	26525534
612	Phosphorylation	RAPSKESSEEEYDSG CCCCCCCCHHHHHCC	50.55	26525534
616	Phosphorylation	KESSEEEYDSGVEED CCCCHHHHHCCCCCC	20.77	21149613
618	Phosphorylation	SSEEEYDSGVEEDGW CCHHHHHCCCCCCCC	43.78	22802335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CLPX_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLPX_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLPX_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CLPX_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.