GGYF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GGYF2_MOUSE
• UniProt AC: Q6Y7W8
• Protein Name: GRB10-interacting GYF protein 2 {ECO:0000303|PubMed:12771153}
• Gene Name: Gigyf2 {ECO:0000303|PubMed:12771153}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1291
• Protein Description: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. [PubMed: 26763119 In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay]
• Protein Sequence: MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAETQTLN ------CCCCCCCCC		-
19	Phosphorylation	PEWLRALSSGGSITS HHHHHHHHCCCCCCC		24925903
20	Phosphorylation	EWLRALSSGGSITSP HHHHHHHCCCCCCCC		24925903
23	Phosphorylation	RALSSGGSITSPPLS HHHHCCCCCCCCCCC		25521595
25	Phosphorylation	LSSGGSITSPPLSPA HHCCCCCCCCCCCCC		25521595
26	Phosphorylation	SSGGSITSPPLSPAL HCCCCCCCCCCCCCC		24925903
30	Phosphorylation	SITSPPLSPALPKYK CCCCCCCCCCCCCCC		24925903
93	Phosphorylation	EEEQRNFSMSVNSAA HHHHHCCCCCCCCEE		-
107	Methylation	AVLRLTGRGGGGGTV EEHHHCCCCCCCCCE		24129315
119	Methylation	GTVVGAPRGRSSSRG CCEECCCCCCCCCCC		24129315
121	Methylation	VVGAPRGRSSSRGRG EECCCCCCCCCCCCC		24129315
140	Phosphorylation	ECGFYQRSFDEVEGV CCCCCCCCHHHCCCC		27149854
150	Methylation	EVEGVFGRGGGREMH HCCCCCCCCCCCCCC		24129315
150	Dimethylation	EVEGVFGRGGGREMH HCCCCCCCCCCCCCC		-
154	Methylation	VFGRGGGREMHRSQS CCCCCCCCCCCCCCC		30989583
159	Phosphorylation	GGREMHRSQSWEERG CCCCCCCCCCHHHHC		27087446
161	Phosphorylation	REMHRSQSWEERGDR CCCCCCCCHHHHCCC		25521595
186	Phosphorylation	GRPNFEESGPTSVGR CCCCCHHCCCCCCCC		25619855
189	Phosphorylation	NFEESGPTSVGRKHE CCHHCCCCCCCCCCC		28066266
190	Phosphorylation	FEESGPTSVGRKHEF CHHCCCCCCCCCCCH		25619855
200	Phosphorylation	RKHEFIRSESENWRI CCCCHHCCCCCCEEE		25266776
202	Phosphorylation	HEFIRSESENWRIFR CCHHCCCCCCEEEEE		27742792
226	Phosphorylation	GGWRLAGSRRDGERW CCEEECCCCCCCCCC		23737553
237	Phosphorylation	GERWRPHSPDGPRST CCCCCCCCCCCCCCC		26824392
243	Phosphorylation	HSPDGPRSTGWREHM CCCCCCCCCCHHHHH		25367039
244	Phosphorylation	SPDGPRSTGWREHME CCCCCCCCCHHHHHH		25367039
274	Phosphorylation	RGYRRVRSGSGSIDD CCCEECCCCCCCCCC		28066266
276	Phosphorylation	YRRVRSGSGSIDDDR CEECCCCCCCCCCCC		26643407
278	Phosphorylation	RVRSGSGSIDDDRDS ECCCCCCCCCCCCCC		28066266
285	Phosphorylation	SIDDDRDSLPEWCLE CCCCCCCCCCHHHHH		23649490
336	Phosphorylation	VEEGEERSDSDSSHN CCCCCCCCCCCCCCC		23375375
338	Phosphorylation	EGEERSDSDSSHNEE CCCCCCCCCCCCCHH		23375375
340	Phosphorylation	EERSDSDSSHNEEAK CCCCCCCCCCCHHHC		23684622
341	Phosphorylation	ERSDSDSSHNEEAKE CCCCCCCCCCHHHCC		23684622
360	Phosphorylation	NRREGEKTDRAGAEA CCCCCCCCCCCCHHC		30387612
368	Phosphorylation	DRAGAEASEEVPQTS CCCCHHCCCCCCCCC		22942356
374	Phosphorylation	ASEEVPQTSLSSARP CCCCCCCCCCCCCCC		27087446
375	Phosphorylation	SEEVPQTSLSSARPG CCCCCCCCCCCCCCC		27742792
377	Phosphorylation	EVPQTSLSSARPGTP CCCCCCCCCCCCCCC		27087446
378	Phosphorylation	VPQTSLSSARPGTPS CCCCCCCCCCCCCCC		27087446
383	Phosphorylation	LSSARPGTPSDHQPQ CCCCCCCCCCCCCCC		27087446
385	Phosphorylation	SARPGTPSDHQPQEA CCCCCCCCCCCCCCC		27742792
393	Phosphorylation	DHQPQEATQFERKDE CCCCCCCCCCCCCCC		27742792
415	Phosphorylation	KAEEENRSENSLSAK HHHHHHCCCCCCCCC		20469934
526	Phosphorylation	EHRAKGVSIPLMHEA HHHHCCCCCHHHHHH		23984901
594	Phosphorylation	MWGRVPFSPGPAPPP HHCCCCCCCCCCCCC		25266776
644	Phosphorylation	YAQVLAQQQKAALSS HHHHHHHHHHHHCCH		24719451
650	Phosphorylation	QQQKAALSSQQQQQL HHHHHHCCHHHHHHH		26745281
651	Phosphorylation	QQKAALSSQQQQQLA HHHHHCCHHHHHHHH		26745281
668	Ubiquitination	LQQFQALKMRMSDQN HHHHHHHHHHCCCCC		22790023
679	Phosphorylation	SDQNIIPSVTRSVSV CCCCCCCCEEEEEEC		24759943
681	O-linked_Glycosylation	QNIIPSVTRSVSVPD CCCCCCEEEEEECCC		55414289
681	Phosphorylation	QNIIPSVTRSVSVPD CCCCCCEEEEEECCC		24759943
683	Phosphorylation	IIPSVTRSVSVPDTG CCCCEEEEEECCCCC		23649490
685	Phosphorylation	PSVTRSVSVPDTGSI CCEEEEEECCCCCCC		23649490
987	Ubiquitination	QQQQQQQKLSGWGNV HHHHHHHHHHCCCCC		22790023
995	Phosphorylation	LSGWGNVSKPAGTTK HHCCCCCCCCCCCCH		-
996	Ubiquitination	SGWGNVSKPAGTTKS HCCCCCCCCCCCCHH		22790023
1090	Ubiquitination	GFWDDAVKEVGPRNS CCCHHHHHHHCCCCC		22790023
1109	Ubiquitination	KNNASLSKSVGVSNR CCCCHHHHHHCCCHH		22790023
1110	Phosphorylation	NNASLSKSVGVSNRQ CCCHHHHHHCCCHHC		29514104
1126	Acetylation	KKVEEEEKLLKLFQG CCHHHHHHHHHHHHC		23806337
1126	Succinylation	KKVEEEEKLLKLFQG CCHHHHHHHHHHHHC		23806337
1129	Ubiquitination	EEEEKLLKLFQGVNK HHHHHHHHHHHCHHH		22790023
1172	Phosphorylation	SFLKEVESPYEVHDY HHHHHCCCCCCCCCC		29514104
1174	Phosphorylation	LKEVESPYEVHDYTR HHHCCCCCCCCCCHH		22817900
1191	Ubiquitination	LGDTSEAKEFAKQFL CCCHHHHHHHHHHHH		22790023
1233	Phosphorylation	MNHSTLHSVFQTNQS CCHHHHHHHHCCCCC		22802335
1267	Phosphorylation	KMVRADPSLLGFSVN HHCCCCHHHHCCCCC		25619855
1272	Phosphorylation	DPSLLGFSVNASSER CHHHHCCCCCCCCCC		25619855
1276	Phosphorylation	LGFSVNASSERLNMG HCCCCCCCCCCCCCC		25521595
1277	Phosphorylation	GFSVNASSERLNMGE CCCCCCCCCCCCCCC		25619855
1291	Phosphorylation	EIETLDDY------- CCCCCCCC-------		24224561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
30	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GGYF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GGYF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GGYF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.