RER1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RER1_MOUSE
• UniProt AC: Q9CQU3
• Protein Name: Protein RER1
• Gene Name: Rer1
• Organism: Mus musculus (Mouse).
• Sequence Length: 196
• Subcellular Localization: Golgi apparatus membrane; Multi-pass membrane protein.
• Protein Description: Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment..
• Protein Sequence: MSEGDSVGDSVHGKPSVVYRFFSRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMICTFFEAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYKGKEDVGKTFAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEGDSVGD ------CCCCCCCCC	50.73	-
2	Phosphorylation	------MSEGDSVGD ------CCCCCCCCC	50.73	23684622
6	Phosphorylation	--MSEGDSVGDSVHG --CCCCCCCCCCCCC	38.57	23684622
10	Phosphorylation	EGDSVGDSVHGKPSV CCCCCCCCCCCCHHH	15.30	22807455
14	Acetylation	VGDSVHGKPSVVYRF CCCCCCCCHHHHHHH	21.17	23954790
14	Ubiquitination	VGDSVHGKPSVVYRF CCCCCCCCHHHHHHH	21.17	-
90	Phosphorylation	LSPKVDPSLMEDSDD HCCCCCHHHCCCCCC	35.57	28833060
92	Oxidation	PKVDPSLMEDSDDGP CCCCHHHCCCCCCCC	6.71	17242355
95	Phosphorylation	DPSLMEDSDDGPSLP CHHHCCCCCCCCCCC	25.05	27087446
100	Phosphorylation	EDSDDGPSLPTKQNE CCCCCCCCCCCCCCH	53.13	28833060
104	Ubiquitination	DGPSLPTKQNEEFRP CCCCCCCCCCHHCHH	49.54	-
171	Ubiquitination	RQIKHMIKYRYIPFT HHHHHHHHHCCCCCC	18.99	-
181	Ubiquitination	YIPFTHGKRRYKGKE CCCCCCCCCCCCCCC	26.54	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RER1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RER1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RER1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYVN1_HUMAN	SYVN1	physical	23129766
CALX_MOUSE	Canx	physical	23129766
NICA_MOUSE	Ncstn	physical	23129766
STX6_MOUSE	Stx6	physical	23129766

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.
PubMed: 17242355

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-95, AND MASSSPECTROMETRY.
PubMed: 17203969