DCHS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCHS_MOUSE
• UniProt AC: P23738
• Protein Name: Histidine decarboxylase
• Gene Name: Hdc
• Organism: Mus musculus (Mouse).
• Sequence Length: 662
• Protein Description: Catalyzes the biosynthesis of histamine from histidine..
• Protein Sequence: MMEPCEYREYREYYRARGKEMVDYISQYLSTVRERQVTPNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSSRGGGVLQSTVSESTLIALLAARKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFLPVDDNFSLRGEALQKAIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLWLHVDAAYAGTAFLCPELRGFLEGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGAATDFMHWQIPLSRRFRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTESVLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDWHLIQEAANLVLSQHCTSQPSPRAKNVIPPPPGTRGLSLESVSEGGDDPAQARKIIKQPGASLARREGGSDLETMPDPFDDCFSEEAPNTTKHKLSSFLFSYLSVQNRRKTTRSLSCNSVPMSAQKSLPADASLKNGGSFRARIFSGFPEQMMMMKKGAFKKLIKFYSVPSFPECSSQCARQLPCCPLEAMV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
312	N6-(pyridoxal phosphate)lysine	SFTFNPSKWMMVHFD EEEECHHHEEEEEEE	40.12	-
312	Other	SFTFNPSKWMMVHFD EEEECHHHEEEEEEE	40.12	-
508	Phosphorylation	PPGTRGLSLESVSEG CCCCCCCCCCHHHCC	32.68	30635358
511	Phosphorylation	TRGLSLESVSEGGDD CCCCCCCHHHCCCCC	35.92	-
513	Phosphorylation	GLSLESVSEGGDDPA CCCCCHHHCCCCCHH	39.54	-
566	Phosphorylation	NTTKHKLSSFLFSYL CCCHHHHHHHHHHHH	24.69	25777480
567	Phosphorylation	TTKHKLSSFLFSYLS CCHHHHHHHHHHHHH	36.08	25777480
571	Phosphorylation	KLSSFLFSYLSVQNR HHHHHHHHHHHCCCC	27.58	25777480
572	Phosphorylation	LSSFLFSYLSVQNRR HHHHHHHHHHCCCCC	8.82	25777480
574	Phosphorylation	SFLFSYLSVQNRRKT HHHHHHHHCCCCCCC	17.27	25777480
586	Phosphorylation	RKTTRSLSCNSVPMS CCCCCCCCCCCCCCC	16.70	30387612
589	Phosphorylation	TRSLSCNSVPMSAQK CCCCCCCCCCCCCCC	31.74	26026062

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DCHS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCHS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCHS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DCHS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.