dbPTM

RAB9A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAB9A_MOUSE
UniProt AC	Q9R0M6
Protein Name	Ras-related protein Rab-9A
Gene Name	Rab9a
Organism	Mus musculus (Mouse).
Sequence Length	201
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Endoplasmic reticulum membrane . Golgi apparatus membrane . Late endosome . Cytoplasmic vesicle, phagosome membrane Lipid-anchor Cytoplasmic side . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle
Protein Description	Involved in the transport of proteins between the endosomes and the trans-Golgi network (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. [PubMed: 26620560]
Protein Sequence	MAGKSSLFKIILLGDGGVGKSSLMNRYVTNKFDSQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKTDIKERQVSTEEAQAWCKDNGDYPYFETSAKDSTNVAAAFEEAVRRILATEDRSEHLIQTDTVNLHRKPKPNSSCC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAGKSSLFK ------CCCCCCCEE	33.84	-
6	Phosphorylation	--MAGKSSLFKIILL --CCCCCCCEEEEEC	41.11	25338131
29	Phosphorylation	SLMNRYVTNKFDSQL HHHHHHHHCCCCHHH	24.61	21082442
34	Phosphorylation	YVTNKFDSQLFHTIG HHHCCCCHHHHHEEC	31.73	19060867
103	Ubiquitination	QNLSNWKKEFIYYAD HHHHHCEEEEEEEEE	49.85	-
112	Ubiquitination	FIYYADVKEPESFPF EEEEEECCCCCCCCE	69.01	-
148	Phosphorylation	WCKDNGDYPYFETSA HHHHCCCCCCEECCC	10.96	-
175	Phosphorylation	AVRRILATEDRSEHL HHHHHHCCCCCCCCC	34.67	28978645
179	Phosphorylation	ILATEDRSEHLIQTD HHCCCCCCCCCEECC	41.51	26824392
185	Phosphorylation	RSEHLIQTDTVNLHR CCCCCEECCCCCCCC	27.00	26643407
187	Phosphorylation	EHLIQTDTVNLHRKP CCCEECCCCCCCCCC	18.06	-
200	Geranylgeranylation	KPKPNSSCC------ CCCCCCCCC------	2.99	-
201	Geranylgeranylation	PKPNSSCC------- CCCCCCCC-------	7.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
179	S	Phosphorylation	Kinase	ULK1	O70405	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAB9A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAB9A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RAB9A_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAB9A_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179, AND MASSSPECTROMETRY.	19367708 [Abstract]