SYNC_MOUSE - dbPTM
SYNC_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SYNC_MOUSE
UniProt AC Q8BP47
Protein Name Asparagine--tRNA ligase, cytoplasmic
Gene Name Nars
Organism Mus musculus (Mouse).
Sequence Length 559
Subcellular Localization Cytoplasm.
Protein Description
Protein Sequence MSSEVIRGTAEMVLAELYVSDREGNDATGDGTKEKPFKTGLKALMTVGKEPFPTIYVDSQKENERWDVISKSQMKNIKKMWHREQMKNDSREKKEAEDNLRREKNLEEAKKIIIKNDPSLPEPACVKISALEGYRGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLSDDLCQCYNGVVLSTESSVAVYGTLNLTPKGKQAPGGHELSCDFWELVGLAPAGGADNLINEESDVDVQLNNRHMMIRGENMSKILKARSMITRCFRDHFFDRGYCEVTTPTLVQTQVEGGATLFKLDYFGEEAFLTQSSQLYLETCLPALGDVFCIAQSYRAEQSRTRRHLAEFTHVEAECPFLTFEDLLNRLEDLVCDVVDRVLKSPVASIVYELNPNFKPPKRPFRRMNYSDAIEWLKEHDVKKEDGTFYEFGDDIPEAPERLMTDTINEPILLCRFPVEIKSFYMQRCPEDPRLTESVDVLMPNVGEIVGGSMRSWDSEEILEGYKREGIDPAPYYWYTDQRKYGTCPHGGYGLGLERFLSWILNRYHIRDVCLYPRFLQRCRP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSEVIRGT
------CCHHHHHHH		34.8922006019
9PhosphorylationSSEVIRGTAEMVLAE
CHHHHHHHHHHHEEE		15.0322871156
28PhosphorylationDREGNDATGDGTKEK
CCCCCCCCCCCCCCC		38.3722871156
49UbiquitinationKALMTVGKEPFPTIY
HHHHHCCCCCCCEEE		58.8522790023
70PhosphorylationNERWDVISKSQMKNI
CCCCCCCCHHHHHHH		26.5529514104
71AcetylationERWDVISKSQMKNIK
CCCCCCCHHHHHHHH		33.3223806337
71MalonylationERWDVISKSQMKNIK
CCCCCCCHHHHHHHH		33.3226320211
71SuccinylationERWDVISKSQMKNIK
CCCCCCCHHHHHHHH		33.3223806337
72PhosphorylationRWDVISKSQMKNIKK
CCCCCCHHHHHHHHH		28.8129514104
75MalonylationVISKSQMKNIKKMWH
CCCHHHHHHHHHHHH		48.1326320211
115AcetylationEAKKIIIKNDPSLPE
HHHHHHHCCCCCCCC		44.9122826441
115UbiquitinationEAKKIIIKNDPSLPE
HHHHHHHCCCCCCCC		44.9122790023
119PhosphorylationIIIKNDPSLPEPACV
HHHCCCCCCCCCCEE		60.4630635358
125GlutathionylationPSLPEPACVKISALE
CCCCCCCEEEEEEEC		4.7224333276
125S-nitrosylationPSLPEPACVKISALE
CCCCCCCEEEEEEEC		4.7221278135
125S-nitrosocysteinePSLPEPACVKISALE
CCCCCCCEEEEEEEC		4.72-
127UbiquitinationLPEPACVKISALEGY
CCCCCEEEEEEECCC		30.72-
140AcetylationGYRGQRVKVFGWVHR
CCCCCEEEEEEHHHH		33.7522826441
255MalonylationIRGENMSKILKARSM
ECCCCHHHHHHHHHH		41.0926320211
255UbiquitinationIRGENMSKILKARSM
ECCCCHHHHHHHHHH		41.09-
255AcetylationIRGENMSKILKARSM
ECCCCHHHHHHHHHH		41.0922826441
277S-nitrosocysteineHFFDRGYCEVTTPTL
HHCCCCCEEECCCCE		3.64-
277S-nitrosylationHFFDRGYCEVTTPTL
HHCCCCCEEECCCCE		3.6422178444
277S-palmitoylationHFFDRGYCEVTTPTL
HHCCCCCEEECCCCE		3.6428526873
277GlutathionylationHFFDRGYCEVTTPTL
HHCCCCCEEECCCCE		3.6424333276
370S-palmitoylationNRLEDLVCDVVDRVL
HHHHHHHHHHHHHHH		4.2328526873
393UbiquitinationYELNPNFKPPKRPFR
EECCCCCCCCCCCCC		68.0322790023
449GlutathionylationINEPILLCRFPVEIK
CCCCEEEECCCEEEH		3.6524333276
449S-palmitoylationINEPILLCRFPVEIK
CCCCEEEECCCEEEH		3.6528526873
456UbiquitinationCRFPVEIKSFYMQRC
ECCCEEEHEEHHHCC		22.4722790023
481PhosphorylationDVLMPNVGEIVGGSM
CEECCCCHHHCCCCC		26.0817203969
490PhosphorylationIVGGSMRSWDSEEIL
HCCCCCCCCCHHHHH		26.9629899451
493PhosphorylationGSMRSWDSEEILEGY
CCCCCCCHHHHHHHH		30.7617203969
501AcetylationEEILEGYKREGIDPA
HHHHHHHHHCCCCCC		55.6323806337
501UbiquitinationEEILEGYKREGIDPA
HHHHHHHHHCCCCCC		55.6322790023
518AcetylationYWYTDQRKYGTCPHG
EEECCCCCCCCCCCC		42.2622826441
522S-palmitoylationDQRKYGTCPHGGYGL
CCCCCCCCCCCCCCH		1.7128526873
522S-nitrosylationDQRKYGTCPHGGYGL
CCCCCCCCCCCCCCH		1.7120925432
522S-nitrosocysteineDQRKYGTCPHGGYGL
CCCCCCCCCCCCCCH		1.71-
548GlutathionylationRYHIRDVCLYPRFLQ
HHCHHHHHHHHHHHH		3.3624333276
550PhosphorylationHIRDVCLYPRFLQRC
CHHHHHHHHHHHHHC		6.29-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SYNC_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SYNC_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SYNC_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of SYNC_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SYNC_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-493, AND MASSSPECTROMETRY.

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