TRML1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRML1_MOUSE
• UniProt AC: Q8K558
• Protein Name: Trem-like transcript 1 protein
• Gene Name: Treml1
• Organism: Mus musculus (Mouse).
• Sequence Length: 317
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cytoplasm . Sequestered in cytoplasmic vesicles in resting platelets. Transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis
• Protein Description: Cell surface receptor that may play a role in the innate and adaptive immune response..
• Protein Sequence: MDCYLLLLLLLLGLAGQGSADSHPEVLQAPVGSSILVQCHYRLQDVRALKVWCQFLQEGCHPLVTSAVDRRAPGNGRIFLTDLGGGLLQVEMVTLQEEDTGEYGCVVEGAAGPQTLHRVSLLVLPPVPGPREGEEAEDEKETYRIGTGSLLEDPSLDPSASAGPHEFRRRENSIPLIWGAVLLLALVVVAVVIFAVMARKKGNRLVVCGPSQSTGVPGMDPPSAAHRSSDSGLPSDIPHVRLDSPPSFDSIYTGSSLDPPSSEPPAPPSQPPLPPKVLMSSKSVTYATVVFPGGDKGKIASCEPVQDPPNSQTPPSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
208	S-palmitoylation	KGNRLVVCGPSQSTG CCCEEEEECCCCCCC	5.31	-
211	Phosphorylation	RLVVCGPSQSTGVPG EEEEECCCCCCCCCC	23.26	29472430
213	Phosphorylation	VVCGPSQSTGVPGMD EEECCCCCCCCCCCC	31.31	29472430
214	Phosphorylation	VCGPSQSTGVPGMDP EECCCCCCCCCCCCC	34.26	29472430
228	Phosphorylation	PPSAAHRSSDSGLPS CCCHHHCCCCCCCCC	28.73	25521595
229	Phosphorylation	PSAAHRSSDSGLPSD CCHHHCCCCCCCCCC	35.43	27742792
231	Phosphorylation	AAHRSSDSGLPSDIP HHHCCCCCCCCCCCC	44.15	28833060
233	Phosphorylation	HRSSDSGLPSDIPHV HCCCCCCCCCCCCCE	4.20	24719451
235	Phosphorylation	SSDSGLPSDIPHVRL CCCCCCCCCCCCEEC	53.89	28833060
283	Phosphorylation	KVLMSSKSVTYATVV CEEECCCCEEEEEEE	22.95	25521595
285	Phosphorylation	LMSSKSVTYATVVFP EECCCCEEEEEEEEC	17.96	27742792
286	Phosphorylation	MSSKSVTYATVVFPG ECCCCEEEEEEEECC	9.71	29472430
288	Phosphorylation	SKSVTYATVVFPGGD CCCEEEEEEEECCCC	13.54	25521595
296	Ubiquitination	VVFPGGDKGKIASCE EEECCCCCCCEEECC	66.43	-
298	Ubiquitination	FPGGDKGKIASCEPV ECCCCCCCEEECCCC	40.62	-
311	Phosphorylation	PVQDPPNSQTPPSK- CCCCCCCCCCCCCC-	41.00	29472430
313	Phosphorylation	QDPPNSQTPPSK--- CCCCCCCCCCCC---	36.67	29472430
316	Phosphorylation	PNSQTPPSK------ CCCCCCCCC------	52.80	29472430

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRML1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRML1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRML1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRML1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Mitochondrial phosphoproteome revealed by an improved IMAC method andMS/MS/MS.";
Lee J., Xu Y., Chen Y., Sprung R., Kim S.C., Xie S., Zhao Y.;
Mol. Cell. Proteomics 6:669-676(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-228, AND MASSSPECTROMETRY.
PubMed: 17208939

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-285, AND MASSSPECTROMETRY.
PubMed: 17242355