DHRS1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DHRS1_MOUSE
• UniProt AC: Q99L04
• Protein Name: Dehydrogenase/reductase SDR family member 1
• Gene Name: Dhrs1
• Organism: Mus musculus (Mouse).
• Sequence Length: 313
• Protein Sequence: MVAPMKGQVCVVTGASRGIGRGIALQLCKAGATVYITGRHLDTLRATAQEAQSLGGRCVPVVCDSSQESEVKSLFEQVDREQKGRLDVLVNNAYAGVQAILNTTNKSFWEVPASIWDDINNVGLRGHYLCSVYGARLMVPAGKGLIVIVSSPGGLQHMFNVPYGVGKAACDRLAADCAHELRRHGVSYVSLWPGLVQTEMVKEFMAKEDTPEDPLFKKMKPDFSSAESPEMSGKCVVALATDPNILNLSGKVLPSCDLARRYGLKDIDGRPVKDYFSLGYALSQVSSLGWLNSFLPGFLRVPKWVVTLYNSKF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Malonylation	--MVAPMKGQVCVVT --CCCCCCCCEEEEE	45.17	26320211
6	Ubiquitination	--MVAPMKGQVCVVT --CCCCCCCCEEEEE	45.17	-
10	S-nitrosocysteine	APMKGQVCVVTGASR CCCCCCEEEEECCCC	1.24	-
10	S-palmitoylation	APMKGQVCVVTGASR CCCCCCEEEEECCCC	1.24	28526873
10	S-nitrosylation	APMKGQVCVVTGASR CCCCCCEEEEECCCC	1.24	21278135
10	Glutathionylation	APMKGQVCVVTGASR CCCCCCEEEEECCCC	1.24	24333276
21	Methylation	GASRGIGRGIALQLC CCCCCCCHHHHHHHH	31.27	24129315
28	S-palmitoylation	RGIALQLCKAGATVY HHHHHHHHHCCCEEE	1.51	28526873
29	Ubiquitination	GIALQLCKAGATVYI HHHHHHHHCCCEEEE	59.45	-
33	Phosphorylation	QLCKAGATVYITGRH HHHHCCCEEEEECCC	16.96	29899451
35	Phosphorylation	CKAGATVYITGRHLD HHCCCEEEEECCCHH	6.60	29899451
47	Phosphorylation	HLDTLRATAQEAQSL CHHHHHHHHHHHHHC	23.57	29899451
72	Acetylation	SSQESEVKSLFEQVD CCCHHHHHHHHHHHC	37.07	23201123
83	Acetylation	EQVDREQKGRLDVLV HHHCHHHCCCHHHHC	41.04	23201123
83	Ubiquitination	EQVDREQKGRLDVLV HHHCHHHCCCHHHHC	41.04	22790023
130	Glutathionylation	GLRGHYLCSVYGARL CCCCHHHHHHCCCEE	1.72	24333276
130	S-palmitoylation	GLRGHYLCSVYGARL CCCCHHHHHHCCCEE	1.72	28526873
133	Phosphorylation	GHYLCSVYGARLMVP CHHHHHHCCCEEEEE	6.70	26032504
177	S-palmitoylation	CDRLAADCAHELRRH HHHHHHHHHHHHHHC	3.41	28526873
177	S-nitrosocysteine	CDRLAADCAHELRRH HHHHHHHHHHHHHHC	3.41	-
177	S-nitrosylation	CDRLAADCAHELRRH HHHHHHHHHHHHHHC	3.41	21278135
207	Ubiquitination	MVKEFMAKEDTPEDP HHHHHHCCCCCCCCC	44.31	22790023
217	Acetylation	TPEDPLFKKMKPDFS CCCCCHHHHCCCCCC	60.69	23201123
218	Acetylation	PEDPLFKKMKPDFSS CCCCHHHHCCCCCCC	44.84	30985811
234	Acetylation	ESPEMSGKCVVALAT CCCCCCCCEEEEEEC	19.29	30985815
255	Phosphorylation	LSGKVLPSCDLARRY CCCCCCCCCHHHHHH	18.99	28066266
256	S-palmitoylation	SGKVLPSCDLARRYG CCCCCCCCHHHHHHC	4.73	28526873
265	Acetylation	LARRYGLKDIDGRPV HHHHHCCCCCCCCCC	48.55	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DHRS1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DHRS1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DHRS1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DHRS1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.