dbPTM

HS12B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HS12B_MOUSE
UniProt AC	Q9CZJ2
Protein Name	Heat shock 70 kDa protein 12B
Gene Name	Hspa12b
Organism	Mus musculus (Mouse).
Sequence Length	685
Subcellular Localization
Protein Description
Protein Sequence	MLTVPEMGLQGLYISSSPERSPVPSPPGSPRTQESCGIAPLTPSQSPKPEARALQQASFSVVVAIDFGTTSSGYAFSFASDPEAIHMMRKWEGGDPGVAHQKTPTCLLLTPEGIFHSFGYTARDYYHDLDPEEARDWLYFEKFKMKIHSATDLTLKTQLEAVNGKKMLALEVFAHALRFFKEHALQELREQSECMLEKGAVRWVLTVPAIWKQPAKQFMREAAYLAGLVSREDAEKLLIALEPEAASVYCRKLRLHQLMDLSSRTAGRGRLGERRSIDSSFRHAREQLRRSRHSRTFLVEAGVGELWAEMQEGDRYMVADCGGGTVDLTVHQLEQPHGTLKELYKASGGPYGAVGVDLAFEQLLCRIFGEDFIAKFKRQRPAAWVDLTIAFEARKRTAGPHRAGALNISLPFSFIDFYRKQRGHNVETALRRSSVNLVKWSSQGMLRMSCEAMNELFQPTVSGIIQHIEMLLAKPEVQGVKLLFLVGGFAESAVLQHAVQEALGTRGLRVVVPHDVGLTILKGAVLFGQAPGVVRVRRSPLTYGVGVLNRFVPGHHPPEKLLVRDGRRWCTDVFERFVAAEQSVALGEEVRRSYCPARPGQRRVLINLYCCAAEDARFITDPGVRKCGALSLELEPEGCPENTGTSPSRREIRAAMQFGDTEIKVTAVDVSTNRSVRAAIDFLSN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MLTVPEMGLQ -----CCCCCCCCCE	32.49	23737553
13	Phosphorylation	EMGLQGLYISSSPER CCCCEEEEECCCCCC	12.94	23737553
15	Phosphorylation	GLQGLYISSSPERSP CCEEEEECCCCCCCC	15.94	23737553
16	Phosphorylation	LQGLYISSSPERSPV CEEEEECCCCCCCCC	40.11	23737553
17	Phosphorylation	QGLYISSSPERSPVP EEEEECCCCCCCCCC	24.80	23737553
21	Phosphorylation	ISSSPERSPVPSPPG ECCCCCCCCCCCCCC	28.70	25619855
25	Phosphorylation	PERSPVPSPPGSPRT CCCCCCCCCCCCCCC	43.92	25521595
29	Phosphorylation	PVPSPPGSPRTQESC CCCCCCCCCCCCCCC	19.58	25521595
32	Phosphorylation	SPPGSPRTQESCGIA CCCCCCCCCCCCCCC	39.82	25619855
35	Phosphorylation	GSPRTQESCGIAPLT CCCCCCCCCCCCCCC	14.07	25619855
42	Phosphorylation	SCGIAPLTPSQSPKP CCCCCCCCCCCCCCH	21.60	25521595
44	Phosphorylation	GIAPLTPSQSPKPEA CCCCCCCCCCCCHHH	37.75	27742792
46	Phosphorylation	APLTPSQSPKPEARA CCCCCCCCCCHHHHH	38.95	25521595
146	Ubiquitination	YFEKFKMKIHSATDL HHHHHCCEECCCCCC	37.55	22790023
181	Ubiquitination	AHALRFFKEHALQEL HHHHHHHHHHHHHHH	45.97	22790023
198	Methylation	QSECMLEKGAVRWVL HCCHHHHCCCEEEEE	48.48	-
198	Ubiquitination	QSECMLEKGAVRWVL HCCHHHHCCCEEEEE	48.48	22790023
249	Phosphorylation	EPEAASVYCRKLRLH CHHHHHHHHHHHHHH	5.53	29514104
276	Phosphorylation	GRLGERRSIDSSFRH CCCCCCCCCCHHHHH	36.65	25521595
279	Phosphorylation	GERRSIDSSFRHARE CCCCCCCHHHHHHHH	29.70	27742792
280	Phosphorylation	ERRSIDSSFRHAREQ CCCCCCHHHHHHHHH	23.66	27742792
294	Phosphorylation	QLRRSRHSRTFLVEA HHHHCHHHCEEEEEC	31.72	29899451
375	Acetylation	FGEDFIAKFKRQRPA HCHHHHHHHHHCCCC	46.75	22902405
375	Ubiquitination	FGEDFIAKFKRQRPA HCHHHHHHHHHCCCC	46.75	22790023
433	Phosphorylation	VETALRRSSVNLVKW HHHHHHHHCCHHEEE	32.00	23984901
434	Phosphorylation	ETALRRSSVNLVKWS HHHHHHHCCHHEEEC	17.14	25521595
441	Phosphorylation	SVNLVKWSSQGMLRM CCHHEEECCHHHHHH	13.68	22324799
442	Phosphorylation	VNLVKWSSQGMLRMS CHHEEECCHHHHHHH	29.64	22817900
598	Dimethylation	RRSYCPARPGQRRVL HHHHCCCCCCCCEEE	22.48	-
598	Methylation	RRSYCPARPGQRRVL HHHHCCCCCCCCEEE	22.48	58856151
664	Ubiquitination	QFGDTEIKVTAVDVS HHCCCEEEEEEEECC	27.57	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HS12B_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HS12B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HS12B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of HS12B_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HS12B_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-42, AND MASSSPECTROMETRY.	17242355 [Abstract]