ASPH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASPH_MOUSE
• UniProt AC: Q8BSY0
• Protein Name: Aspartyl/asparaginyl beta-hydroxylase
• Gene Name: Asph
• Organism: Mus musculus (Mouse).
• Sequence Length: 741
• Subcellular Localization: Isoform 1: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .; Isoform 2: Sarcoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins..
• Protein Sequence: MAPRKNAKGGGGNSSSSGSGSGSGSGSPSTGSSGSSSSPGARREAKHGGHKNGRRGGISGGSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGVYDADGDGDFDVDDAKVLLGLKERSPSERTFPPEEEAETHAELEEQAPEGADIQNVEDEVKEQIQSLLQESVHTDHDLEADGLAGEPQPEVEDFLTVTDSDDRFEDLEPGTVHEEIEDTYHVEDTASQNHPNDMEEMTNEQENSDPSEAVTDAGVLLPHAEEVRHQDYDEPVYEPSEHEGVAISDNTIDDSSIISEEINVASVEEQQDTPPVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFEELVRKYPQSPRARYGKAQCEDDLAEKQRSNEVLRRAIETYQEAADLPDAPTDLVKLSLKRRSERQQFLGHMRGSLLTLQRLVQLFPSDTTLKNDLGVGYLLLGDNDSAKKVYEEVLNVTPNDGFAKVHYGFILKAQNKISESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPRETGYTELVKSLERNWKLIRDEGLMVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRKNENACKGAPKTCALLEKFSETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETRTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	AKGGGGNSSSSGSGS CCCCCCCCCCCCCCC	34.57	25159016
15	Phosphorylation	KGGGGNSSSSGSGSG CCCCCCCCCCCCCCC	32.30	25159016
16	Phosphorylation	GGGGNSSSSGSGSGS CCCCCCCCCCCCCCC	38.24	25159016
17	Phosphorylation	GGGNSSSSGSGSGSG CCCCCCCCCCCCCCC	38.64	25159016
19	Phosphorylation	GNSSSSGSGSGSGSG CCCCCCCCCCCCCCC	31.56	25159016
21	Phosphorylation	SSSSGSGSGSGSGSP CCCCCCCCCCCCCCC	31.33	25159016
23	Phosphorylation	SSGSGSGSGSGSPST CCCCCCCCCCCCCCC	31.33	25159016
25	Phosphorylation	GSGSGSGSGSPSTGS CCCCCCCCCCCCCCC	37.48	25159016
27	Phosphorylation	GSGSGSGSPSTGSSG CCCCCCCCCCCCCCC	19.85	25159016
29	Phosphorylation	GSGSGSPSTGSSGSS CCCCCCCCCCCCCCC	47.28	25159016
30	Phosphorylation	SGSGSPSTGSSGSSS CCCCCCCCCCCCCCC	44.46	25159016
32	Phosphorylation	SGSPSTGSSGSSSSP CCCCCCCCCCCCCCC	31.45	25159016
33	Phosphorylation	GSPSTGSSGSSSSPG CCCCCCCCCCCCCCC	44.00	25159016
35	Phosphorylation	PSTGSSGSSSSPGAR CCCCCCCCCCCCCCC	29.06	25159016
36	Phosphorylation	STGSSGSSSSPGARR CCCCCCCCCCCCCCH	38.06	25521595
37	Phosphorylation	TGSSGSSSSPGARRE CCCCCCCCCCCCCHH	42.10	25159016
38	Phosphorylation	GSSGSSSSPGARREA CCCCCCCCCCCCHHH	29.33	25159016
119	Ubiquitination	AKVLLGLKERSPSER HHHHHCCCCCCCCCC	49.65	-
354	Phosphorylation	FEELVRKYPQSPRAR HHHHHHHCCCCHHHH	8.92	22668510
357	Phosphorylation	LVRKYPQSPRARYGK HHHHCCCCHHHHHCC	16.32	22668510
447	Phosphorylation	KNDLGVGYLLLGDND CCCCCCEEEEECCCH	7.56	-
453	N-linked_Glycosylation	GYLLLGDNDSAKKVY EEEEECCCHHHHHHH	43.25	-
488	Phosphorylation	LKAQNKISESIPYLK HHHCHHHHHCCCHHH	27.22	22324799
490	Phosphorylation	AQNKISESIPYLKEG HCHHHHHCCCHHHCC	23.28	22324799
493	Phosphorylation	KISESIPYLKEGIES HHHHCCCHHHCCHHC	28.83	22324799
636	Acetylation	KTCALLEKFSETTGC HHHHHHHHHHCCCCC	54.91	22826441
689	N-linked_Glycosylation	GCKIRCANETRTWEE CCEEEECCCCEECCC	55.59	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASPH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASPH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASPH_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ASPH_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.