ATLA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ATLA2_MOUSE
• UniProt AC: Q6PA06
• Protein Name: Atlastin-2
• Gene Name: Atl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 583
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes at endoplasmic reticulum (ER) three-way tubular junctions.
• Protein Description: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis..
• Protein Sequence: MAEGDEAARRQQPQQGLRRRRQTSDSSVGVNHVSSTTSLGEDYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDVYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVALKQFRSVKKMGGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLALTSLCTWAYVKYSGEFREIGTMIDQIAETLWEQVLKPLGDNLMEENIRQSVTNSIKAGLTDQVSHHARLKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	GLRRRRQTSDSSVGV HHHHHHHCCCCCCCC	32.46	26239621
24	Phosphorylation	LRRRRQTSDSSVGVN HHHHHHCCCCCCCCC	27.44	26239621
26	Phosphorylation	RRRQTSDSSVGVNHV HHHHCCCCCCCCCCC	27.04	26239621
27	Phosphorylation	RRQTSDSSVGVNHVS HHHCCCCCCCCCCCC	28.07	26239621
34	Phosphorylation	SVGVNHVSSTTSLGE CCCCCCCCCCCCCCC	17.89	26239621
35	Phosphorylation	VGVNHVSSTTSLGED CCCCCCCCCCCCCCC	34.32	26239621
36	Phosphorylation	GVNHVSSTTSLGEDY CCCCCCCCCCCCCCC	16.94	26239621
37	Phosphorylation	VNHVSSTTSLGEDYE CCCCCCCCCCCCCCC	24.73	26239621
38	Phosphorylation	NHVSSTTSLGEDYED CCCCCCCCCCCCCCC	34.17	26239621
43	Phosphorylation	TTSLGEDYEDDDLVN CCCCCCCCCCCCCCC	19.56	26239621
270	Methylation	LEKRLQVKQNQHEEL HHHHHHHCCHHHHHH	30.48	-
270	Ubiquitination	LEKRLQVKQNQHEEL HHHHHHHCCHHHHHH	30.48	22790023
308	Phosphorylation	LKVATNPSFDGRLKD CEECCCCCCCCCCCC	37.73	30635358
314	Ubiquitination	PSFDGRLKDIDEDFK CCCCCCCCCCCHHHH	51.80	-
314	Malonylation	PSFDGRLKDIDEDFK CCCCCCCCCCCHHHH	51.80	26320211
321	Ubiquitination	KDIDEDFKRELRNLV CCCCHHHHHHHHHHH	58.23	22790023
357	Ubiquitination	RDLVEYFKAYIKIYQ HHHHHHHHHHHHHHC	39.10	22790023
402	S-palmitoylation	CKSMEQVCGGDKPYI CCCHHHHHCCCCCCC	5.15	28526873
422	Ubiquitination	ERKHLDLKEVALKQF HHCCCCHHHHHHHHH	50.22	22790023
427	Ubiquitination	DLKEVALKQFRSVKK CHHHHHHHHHHHHHH	37.34	22790023
461	Ubiquitination	ETYANFIKHNDGKNI HHHHHHHHHCCCCCE	32.02	22790023
567	Ubiquitination	QSVTNSIKAGLTDQV HHHHHHHHHCCCCHH	35.90	22790023
575	Phosphorylation	AGLTDQVSHHARLKT HCCCCHHHHHHCCCC	12.15	20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ATLA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ATLA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ATLA2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ATLA2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.