| UniProt ID | HM13_MOUSE | |
|---|---|---|
| UniProt AC | Q9D8V0 | |
| Protein Name | Minor histocompatibility antigen H13 | |
| Gene Name | Hm13 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 378 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . Membrane Multi-pass membrane protein Lumenal side . Isoform 4: Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection. [PubMed: 9354467] | |
| Protein Sequence | MDSAVSDPHNGSAEAGTPANGTTRPPSTPEGIALAYGSLLLMALLPIFFGALRSVRCARGKSSSDMPETITSRDAARFPIIASCTLLGLYLFFKIFSQEYINLLLSMYFFVLGILALSHTISPFMNKFFPANFPNRQYQLLFTQGSGENKEEIINYEFDTKDLVCLGLSSVVGVWYLLRKHWIANNLFGLAFSLNGVELLHLNNVSTGCILLGGLFIYDIFWVFGTNVMVTVAKSFEAPIKLVFPQDLLEKGLEADNFAMLGLGDIVIPGIFIALLLRFDISLKKNTHTYFYTSFAAYIFGLGLTIFIMHIFKHAQPALLYLVPACIGFPVLVALAKGEVAEMFSYEESNPKDPAAETESKEESTEASASKRLEKKEK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | N-linked_Glycosylation | SAVSDPHNGSAEAGT CCCCCCCCCCCCCCC | 52.05 | - | |
| 20 | N-linked_Glycosylation | AEAGTPANGTTRPPS CCCCCCCCCCCCCCC | 49.93 | - | |
| 61 | Malonylation | SVRCARGKSSSDMPE HHHHHCCCCCCCCCC | 41.43 | 26320211 | |
| 61 | Ubiquitination | SVRCARGKSSSDMPE HHHHHCCCCCCCCCC | 41.43 | - | |
| 62 | Phosphorylation | VRCARGKSSSDMPET HHHHCCCCCCCCCCC | 37.59 | 25159016 | |
| 63 | Phosphorylation | RCARGKSSSDMPETI HHHCCCCCCCCCCCC | 33.57 | 29176673 | |
| 64 | Phosphorylation | CARGKSSSDMPETIT HHCCCCCCCCCCCCC | 45.05 | 25159016 | |
| 241 | Ubiquitination | KSFEAPIKLVFPQDL HHCCCCEEEECCHHH | 37.22 | 22790023 | |
| 356 (in isoform 4) | Phosphorylation | - | 29.63 | 23140645 | |
| 360 | Phosphorylation | DPAAETESKEESTEA CCCCCCCCHHHHHHH | 53.43 | 27841257 | |
| 361 | Ubiquitination | PAAETESKEESTEAS CCCCCCCHHHHHHHH | 60.30 | 22790023 | |
| 364 (in isoform 4) | Phosphorylation | - | 32.41 | 23140645 | |
| 366 (in isoform 4) | Phosphorylation | - | 50.32 | 23984901 | |
| 368 (in isoform 4) | Phosphorylation | - | 27.18 | 26824392 | |
| 368 | Phosphorylation | KEESTEASASKRLEK HHHHHHHHHHHHHHH | 27.18 | 23375375 | |
| 371 (in isoform 4) | Phosphorylation | - | 61.80 | 23984901 | |
| 375 (in isoform 4) | Phosphorylation | - | 71.47 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HM13_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HM13_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HM13_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of HM13_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
