SPIDR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SPIDR_MOUSE
• UniProt AC: Q8BGX7
• Protein Name: DNA repair-scaffolding protein
• Gene Name: Spidr
• Organism: Mus musculus (Mouse).
• Sequence Length: 933
• Subcellular Localization: Nucleus. Together with BLM, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment..
• Protein Description: Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity (By similarity)..
• Protein Sequence: MSGARRPGTSKRKRNWHIEHPSFREERSQQLRRGNFKTVEAADSLSKAWLKCGEGFQDTSEILSLASEKTGITEKHLELSPKPKTETTSKNASELPNIIWSSSESDFSDEDKTLPALQRDGRHGPRADRLGDRTISCPEDEDIEDELQVIDWEVNSDKEDPGGPSECEDDKGTLDISDCDSCASLTSDDRLCEPSEPISTEILEYSSDSEKEEDPEHSLFIDSESPHKYQADFKSDARWCLVSQTDSEANSAEPTLTPQKYTVKFPKTPEYSVTKKKLLRGGLAERLQELQNRKRSAISLWRHRCVSYQMTPLGRKSGVLTVKILELHEECSMQVAVCEQLAGPPITSPPGGLAPRPGAYLKVLFTRETADHLMGHPQDIIYIFPPWQKLLIPNGSCSIILNTYFCQKAIAKETVREDLYSPDISLSRRNITLAQTFRIKDITDNSSINQTTYDSLATPGTGWTHGHEKAEQHLIVAAPLRNSLLDIVESQRAGLWSGVRVQVVVQRVYSLLSRDGARSQQGHTVGHADASGAWSCLLVQDACGMFGEVFLNSTLWKSRQLEGKSCSMSGVKVLQKATRGRTPGLFSLIDSLWPPVISLTEPSCGQPSGETKTYLPPPIFCYIFSAHPTLGQIDAIEDHISKLYQPPVVRCLKEILQTNECSTRCSFYARVIYQKPQLKNLLAQKEIWLLVTDITLQTQDERDHSLPKTLPVYIAPSCVLGPEVVEELALLVSYNLLFRDAFKDNGQIVCIERTVILPQKPLLCVPSASCDLPSPVTLDELSALTPVNSICSVQGTVVDVDESTAFSWPVCDRCGNGRLEQKPEDGGTFSCGDCSQLVLSPLQERHLHVFLDCPTRPESTVKVKLLESSISLLLMSAASEDGSYEVESVLGKEMGPLLCFVQSITTQQSSCVVTLEEIELLSTEGATAAQPPP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
80	Phosphorylation	TEKHLELSPKPKTET CHHHHHCCCCCCCCC		26824392
156	Phosphorylation	VIDWEVNSDKEDPGG EEEEECCCCCCCCCC		25195567
218	Phosphorylation	KEEDPEHSLFIDSES CCCCCCCCCEECCCC		18846507
223	Phosphorylation	EHSLFIDSESPHKYQ CCCCEECCCCCCCEE		22817900
225	Phosphorylation	SLFIDSESPHKYQAD CCEECCCCCCCEECC		18846507
255	Phosphorylation	EANSAEPTLTPQKYT CCCCCCCCCCCCEEE		25619855
257	Phosphorylation	NSAEPTLTPQKYTVK CCCCCCCCCCEEEEE		25619855
261	Phosphorylation	PTLTPQKYTVKFPKT CCCCCCEEEEECCCC		26643407
262	Phosphorylation	TLTPQKYTVKFPKTP CCCCCEEEEECCCCC		26643407
268	Phosphorylation	YTVKFPKTPEYSVTK EEEECCCCCCCCCCH		25338131
308	Phosphorylation	WRHRCVSYQMTPLGR HHHHHCEEECCCCCC		-
311	Phosphorylation	RCVSYQMTPLGRKSG HHCEEECCCCCCCCC		-
421	Phosphorylation	TVREDLYSPDISLSR HHHHHHCCCCCCCHH		25338131
828	Phosphorylation	QKPEDGGTFSCGDCS ECCCCCCCEECCCHH		25293948
830	Phosphorylation	PEDGGTFSCGDCSQL CCCCCCEECCCHHHH		25293948
835	Phosphorylation	TFSCGDCSQLVLSPL CEECCCHHHHEECCH		25293948
840	Phosphorylation	DCSQLVLSPLQERHL CHHHHEECCHHHCCE		28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SPIDR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SPIDR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SPIDR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SPIDR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.