dbPTM

CLPT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLPT1_MOUSE
UniProt AC	Q8VBZ3
Protein Name	Cleft lip and palate transmembrane protein 1 homolog
Gene Name	Clptm1
Organism	Mus musculus (Mouse).
Sequence Length	664
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	May play a role in T-cell development..
Protein Sequence	MAAAQEADGAGSAVVAAGGGSSGQVTSNGSIGRDTPAETQPQNPPPQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPSPQDQSGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAAQSTKSPWNFLGDELYEQSDEEQDSVKVALLETSPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEGLSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLDREHRVAGIFPCPTFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSWVLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGCLRDDVVFFIYLYQRWIYRVDPTRVNEFGMSGEDVSAAASRAQASTAAGALTPAPSTAVSGEDASTVPKATSGACTASQPQEAPPKPAEDKKKD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAQEADG ------CCCHHCCCC	16.11	-
12	Phosphorylation	QEADGAGSAVVAAGG HCCCCCCCEEEECCC	19.84	25293948
21	Phosphorylation	VVAAGGGSSGQVTSN EEECCCCCCCCCCCC	34.27	25293948
22	Phosphorylation	VAAGGGSSGQVTSNG EECCCCCCCCCCCCC	36.20	25293948
26	Phosphorylation	GGSSGQVTSNGSIGR CCCCCCCCCCCCCCC	14.48	25293948
27	Phosphorylation	GSSGQVTSNGSIGRD CCCCCCCCCCCCCCC	40.09	25293948
28	N-linked_Glycosylation	SSGQVTSNGSIGRDT CCCCCCCCCCCCCCC	38.57	-
30	Phosphorylation	GQVTSNGSIGRDTPA CCCCCCCCCCCCCCC	26.56	25293948
119	N-linked_Glycosylation	HEHFTDFNATSALFW CCCCCCCCHHHHHHH	45.15	-
161	N-linked_Glycosylation	IPQSVQQNGSIYIHV CCHHHHHCCEEEEEE	29.14	-
209	Ubiquitination	RRRFQKTKNLLTGET HHHHHHHCCCCCCCC	53.27	22790023
224	Ubiquitination	EADPEMIKRAEDYGP CCCHHHHHHHHHHCC	44.22	22790023
241	N-linked_Glycosylation	VISHWHPNITINIVD EEEECCCCEEEEEEC	31.02	-
295	N-linked_Glycosylation	QKDYYPINESLASLP CCCCCCCCHHHHCCC	28.44	-
308	S-palmitoylation	LPLRVSFCPLSLWRW CCCCEEECCHHHHHH	2.30	28526873
338	Phosphorylation	GDELYEQSDEEQDSV CHHHHHCCHHHCHHH	34.74	26525534
358	Ubiquitination	ETSPYLLALTIIVSI HCCHHHHHHHHHHHH	10.48	27667366
384	Phosphorylation	NDIQFWNSRQSLEGL CCHHHHHCCHHHCCC	23.46	22324799
413	N-linked_Glycosylation	VLLYILDNETNFVVQ HHHHHHCCCCCEEEE	55.32	-
454	S-palmitoylation	RVAGIFPCPTFKDKS CEEEEEECCCCCCCC	3.27	28526873
458	Ubiquitination	IFPCPTFKDKSTYIE EEECCCCCCCCCEEE	67.72	22790023
460	Ubiquitination	PCPTFKDKSTYIESS ECCCCCCCCCEEECC	45.33	27667366
601	Phosphorylation	RVNEFGMSGEDVSAA CCCCCCCCHHHHHHH	39.13	-
606	Phosphorylation	GMSGEDVSAAASRAQ CCCHHHHHHHHHHHH	25.22	17203969
616	Phosphorylation	ASRAQASTAAGALTP HHHHHHHHHCCCCCC	24.44	25619855
622	Phosphorylation	STAAGALTPAPSTAV HHHCCCCCCCCCCCC	19.50	25619855
626	Phosphorylation	GALTPAPSTAVSGED CCCCCCCCCCCCCCC	30.98	30352176
627	Phosphorylation	ALTPAPSTAVSGEDA CCCCCCCCCCCCCCC	29.98	30352176
630	Phosphorylation	PAPSTAVSGEDASTV CCCCCCCCCCCCCCC	33.72	25619855
645	S-nitrosocysteine	PKATSGACTASQPQE CCCCCCCCCCCCCCC	3.59	-
645	S-nitrosylation	PKATSGACTASQPQE CCCCCCCCCCCCCCC	3.59	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLPT1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLPT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLPT1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CLPT1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLPT1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry."; Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.; J. Proteome Res. 6:250-262(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-606, AND MASSSPECTROMETRY.	17203969 [Abstract]