STMN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STMN2_MOUSE
• UniProt AC: P55821
• Protein Name: Stathmin-2
• Gene Name: Stmn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 179
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Cell projection, growth cone . Cell projection, axon . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome. Golgi apparatus. Cell projection, lamellipodium. Colocalized with CIB1 in neurite
• Protein Description: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone..
• Protein Sequence: MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAKTAMAYKEK ----CCHHHHHHHHH	16.48	28576409
16	Phosphorylation	KEKMKELSMLSLICS HHHHHHHHHHHHHHH	20.83	-
22	S-palmitoylation	LSMLSLICSCFYPEP HHHHHHHHHHHCCCC	3.34	-
24	S-palmitoylation	MLSLICSCFYPEPRN HHHHHHHHHCCCCCC	3.08	-
50	Phosphorylation	KQINKRASGQAFELI HHHHHHCCCCEEEEE	35.16	25521595
62	Phosphorylation	ELILKPPSPISEAPR EEEECCCCCCCCCCC	43.31	25521595
65	Phosphorylation	LKPPSPISEAPRTLA ECCCCCCCCCCCCCC	30.96	25521595
73	Phosphorylation	EAPRTLASPKKKDLS CCCCCCCCCCCCCCC	40.12	16618812
80	Phosphorylation	SPKKKDLSLEEIQKK CCCCCCCCHHHHHHH	43.82	25521595
86	Ubiquitination	LSLEEIQKKLEAAEE CCHHHHHHHHHHHHH	66.06	-
97	Phosphorylation	AAEERRKSQEAQVLK HHHHHHHHHHHHHHH	31.29	25521595
119	Ubiquitination	HEREVLQKALEENNN HHHHHHHHHHHHCCC	51.26	-
129	Ubiquitination	EENNNFSKMAEEKLI HHCCCHHHHHHHHHH	37.68	-
143	Methylation	ILKMEQIKENREANL HHHHHHHHHHHHHHH	48.94	-
178	Phosphorylation	KELQVELSG------ HHCCCCCCC------	29.02	20415495

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
62	S	Phosphorylation	Kinase	MAPK8	Q91Y86	GPS
73	S	Phosphorylation	Kinase	MAPK8	Q91Y86	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STMN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STMN2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.