dbPTM

GPDM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPDM_MOUSE
UniProt AC	Q64521
Protein Name	Glycerol-3-phosphate dehydrogenase, mitochondrial
Gene Name	Gpd2
Organism	Mus musculus (Mouse).
Sequence Length	727
Subcellular Localization	Mitochondrion inner membrane.
Protein Description
Protein Sequence	MAFQKAVKGTILVGGGALATVLGLSPFAHYRRKQVSLAYVEAAGYLTEPVNREPPSREAQLMTLKNTPEFDILVIGGGATGCGCALDAVTRGLKTALVERDDFSSGTSSRSTKLIHGGVRYLQKAIMNLDVEQYRMVKEALHERANLLEIAPHLSAPLPIMLPLYKWWQLPYYWVGIKMYDLVAGSQCLKSSYVLSKSRALEHFPMLQKDKLVGAIVYYDGQHNDARMNLAIALTAARYGAATANYMEVVSLLKKTDPETGKERVSGARCKDVLTGQEFDVRAKCVINASGPFTDSVRKMDDKNVVPICQPSAGVHIVMPGYYSPENMGLLDPATSDGRVIFFLPWEKMTIAGTTDTPTDVTHHPIPSEEDINFILNEVRNYLSSDVEVRRGDVLAAWSGIRPLVTDPKSADTQSISRNHVVDISDSGLITIAGGKWTTYRSMAEDTVDAAVKFHNLNAGPSRTVGLFLQGGKDWSPTLYIRLVQDYGLESEVAQHLAKTYGDKAFEVAKMASVTGKRWPVVGVRLVSEFPYIEAEVKYGIKEYACTAVDMISRRTRLAFLNVQAAEEALPRIVELMGRELNWSELRKQEELETATRFLYYEMGYKSRTEQLTDSTEISLLPSDIDRYKKRFHKFDEDEKGFITIVDVQRVLESINVQMDENTLHEILCEVDLNKNGQVELHEFLQLMSAVQKGRVSGSRLAILMKTAEENLDRRVPIPVDRSCGGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
82	S-palmitoylation	IGGGATGCGCALDAV ECCCCCCCHHHHHHH	3.34	28680068
84	S-palmitoylation	GGATGCGCALDAVTR CCCCCCHHHHHHHHC	3.85	28680068
155	Phosphorylation	LEIAPHLSAPLPIML HHHHHHCCCCCCCEE	25.47	-
165	Phosphorylation	LPIMLPLYKWWQLPY CCCEEHHHHHHCCCC	11.56	-
186	Phosphorylation	MYDLVAGSQCLKSSY HHHHHHCCHHHHHHH	14.16	28464351
188	S-palmitoylation	DLVAGSQCLKSSYVL HHHHCCHHHHHHHHC	5.75	28526873
198	Phosphorylation	SSYVLSKSRALEHFP HHHHCCCCHHHHHCC	21.29	29899451
270	S-nitrosylation	ERVSGARCKDVLTGQ CCCCCCCHHCCCCCC	4.35	22178444
285	S-nitrosylation	EFDVRAKCVINASGP CEEEEEEEEEECCCC	3.47	24895380
362	Phosphorylation	TDTPTDVTHHPIPSE CCCCCCCCCCCCCCH	19.78	28464351
384	Phosphorylation	NEVRNYLSSDVEVRR HHHHHHHCCCCEEEC	17.71	20415495
385	Phosphorylation	EVRNYLSSDVEVRRG HHHHHHCCCCEEECC	42.98	26525534
415	Phosphorylation	PKSADTQSISRNHVV CCCCCCCCCCCCCEE	25.32	23684622
436	Malonylation	LITIAGGKWTTYRSM CEEEECCEEEEEHHH	40.21	26073543
447	Phosphorylation	YRSMAEDTVDAAVKF EHHHHCCHHHHHHHH	16.28	22871156
510	Ubiquitination	DKAFEVAKMASVTGK HHHHHHHHHHHCCCC	39.93	-
532	Phosphorylation	RLVSEFPYIEAEVKY EEEEECCEEEEEHHH	19.40	21082442
546	S-palmitoylation	YGIKEYACTAVDMIS HCCHHHHHHHHHHHH	2.16	28526873
600	Phosphorylation	ETATRFLYYEMGYKS HHHHHHHHHHCCCCC	8.48	18034455
601	Phosphorylation	TATRFLYYEMGYKSR HHHHHHHHHCCCCCC	11.11	29899451
607	Phosphorylation	YYEMGYKSRTEQLTD HHHCCCCCCCCCCCC	35.63	26239621
609	Phosphorylation	EMGYKSRTEQLTDST HCCCCCCCCCCCCCC	34.86	30635358
613	Phosphorylation	KSRTEQLTDSTEISL CCCCCCCCCCCCEEC	27.83	30635358
615	Phosphorylation	RTEQLTDSTEISLLP CCCCCCCCCCEECCC	23.78	30635358
616	Phosphorylation	TEQLTDSTEISLLPS CCCCCCCCCEECCCH	39.90	30635358
619	Phosphorylation	LTDSTEISLLPSDID CCCCCCEECCCHHHH	20.02	30635358
623	Phosphorylation	TEISLLPSDIDRYKK CCEECCCHHHHHHHH	47.36	30635358
634	Succinylation	RYKKRFHKFDEDEKG HHHHHHHCCCCCCCC	52.37	23954790
634	Acetylation	RYKKRFHKFDEDEKG HHHHHHHCCCCCCCC	52.37	23864654
697	Phosphorylation	AVQKGRVSGSRLAIL HHHCCCCCHHHHHHH	29.68	24759943
699	Phosphorylation	QKGRVSGSRLAILMK HCCCCCHHHHHHHHH	19.33	22817900
723	Phosphorylation	VPIPVDRSCGGL--- CCCCCCCCCCCC---	16.79	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPDM_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPDM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPDM_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of GPDM_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPDM_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-600 AND TYR-601, ANDMASS SPECTROMETRY.	18034455 [Abstract]