ABD12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABD12_MOUSE
• UniProt AC: Q99LR1
• Protein Name: Monoacylglycerol lipase ABHD12 {ECO:0000305}
• Gene Name: Abhd12 {ECO:0000312|MGI:MGI:1923442}
• Organism: Mus musculus (Mouse).
• Sequence Length: 398
• Subcellular Localization: Membrane ; Single-pass membrane protein . Mitochondrion .
• Protein Description: Lysophosphatidylserine (LPS) lipase that plays a key role in the central nervous system. Represents a major LPS lipase in the brain. [PubMed: 23297193 May also have a 2-arachidonoylglycerol (2-AG) hydrolase activity and act as a regulator of endocannabinoid signaling pathways]
• Protein Sequence: MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHAIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MRKRTEPVTLEH ---CCCCCCCCEECC	47.91	29899451
52	Phosphorylation	KGTAEPHSASDAGMK CCCCCCCCCCHHHHH	39.94	30635358
54	Phosphorylation	TAEPHSASDAGMKRA CCCCCCCCHHHHHHH	30.89	30635358
59	Ubiquitination	SASDAGMKRALGRRK CCCHHHHHHHHCCCH	33.33	27667366
67	Phosphorylation	RALGRRKSLWFRLRK HHHCCCHHHHHHHHH	29.08	18816981
123	N-linked_Glycosylation	KPQDQGLNHTCNYYL CCCCCCCCCCCCEEE	34.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABD12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABD12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABD12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ABD12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.