FUBP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUBP1_MOUSE
• UniProt AC: Q91WJ8
• Protein Name: Far upstream element-binding protein 1
• Gene Name: Fubp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 651
• Subcellular Localization: Nucleus .
• Protein Description: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity)..
• Protein Sequence: MADYSTVPPPSSGSAGGGGGGVVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVPPQNDSFGAQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPDRIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRSPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGGPVNPLGPPVPHGPHGVPGPHGPPGPPGPGTPMGPYNPAPYNPGPPGPAPHGPPAPYAPQGWGNAYPHWQQQAPPDPAKAGADPNSAAWAAYYAHYYQQQAQPPPAAPAGAPATTQTNGQGDQQAPAPAGQVDYTKAWEEYYKKMGQAVPAPAGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGFANHARSHHHLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADYSTVPP ------CCCCCCCCC	25.17	-
11	Phosphorylation	YSTVPPPSSGSAGGG CCCCCCCCCCCCCCC	53.78	25338131
12	Phosphorylation	STVPPPSSGSAGGGG CCCCCCCCCCCCCCC	42.41	25338131
47	Phosphorylation	KIGGDAGTSLNSNDY HHCCCCCCCCCCCCC	31.59	30635358
48	Phosphorylation	IGGDAGTSLNSNDYG HCCCCCCCCCCCCCC	25.33	27566939
51	Phosphorylation	DAGTSLNSNDYGYGG CCCCCCCCCCCCCCC	36.05	30635358
54	Phosphorylation	TSLNSNDYGYGGQKR CCCCCCCCCCCCCCC	19.25	30635358
56	Phosphorylation	LNSNDYGYGGQKRPL CCCCCCCCCCCCCCC	16.32	30635358
60	Ubiquitination	DYGYGGQKRPLEDGD CCCCCCCCCCCCCCC	60.29	-
74 (in isoform 2)	Phosphorylation	-	9.12	26643407
75 (in isoform 2)	Phosphorylation	-	33.37	26643407
76 (in isoform 2)	Phosphorylation	-	48.90	26643407
77 (in isoform 2)	Phosphorylation	-	61.36	26643407
80	Phosphorylation	KVPPQNDSFGAQLPP CCCCCCCCCCCCCCC	32.88	28285833
84 (in isoform 2)	Phosphorylation	-	55.68	25266776
93	Phosphorylation	PPMHQQQSRSVMTEE CCHHHHHCCCCCCCE	23.37	28285833
95	Phosphorylation	MHQQQSRSVMTEEYK HHHHHCCCCCCCEEC	22.84	28833060
98	Phosphorylation	QQSRSVMTEEYKVPD HHCCCCCCCEECCCC	24.41	28833060
101	Phosphorylation	RSVMTEEYKVPDGMV CCCCCCEECCCCCCE	15.85	28833060
128	Glutathionylation	RIQQESGCKIQIAPD HHHHHHCCEEEECCC	4.96	24333276
136	Phosphorylation	KIQIAPDSGGLPERS EEEECCCCCCCCCCC	33.43	28833060
143	Phosphorylation	SGGLPERSCMLTGTP CCCCCCCCEECCCCH	11.39	23527152
144	S-nitrosocysteine	GGLPERSCMLTGTPE CCCCCCCEECCCCHH	3.03	-
144	S-nitrosylation	GGLPERSCMLTGTPE CCCCCCCEECCCCHH	3.03	21278135
144	Glutathionylation	GGLPERSCMLTGTPE CCCCCCCEECCCCHH	3.03	24333276
147	Phosphorylation	PERSCMLTGTPESVQ CCCCEECCCCHHHHH	16.48	28066266
149	Phosphorylation	RSCMLTGTPESVQSA CCEECCCCHHHHHHH	20.74	23527152
152	Phosphorylation	MLTGTPESVQSAKRL ECCCCHHHHHHHHHH	27.02	28066266
199	Ubiquitination	KAGLVIGKGGETIKQ HCCEEECCCCHHHHH	53.25	-
199	Acetylation	KAGLVIGKGGETIKQ HCCEEECCCCHHHHH	53.25	24494799
205	Ubiquitination	GKGGETIKQLQERAG CCCCHHHHHHHHHHC	52.99	-
317	Methylation	DDGTTPDRIAQITGP CCCCCCCHHHHHHCC	27.61	24129315
328	S-palmitoylation	ITGPPDRCQHAAEII HHCCCHHHHHHHHHH	4.54	26165157
355	Dimethylation	GGPGPGGRGRGRGQG CCCCCCCCCCCCCCC	37.23	-
355	Methylation	GGPGPGGRGRGRGQG CCCCCCCCCCCCCCC	37.23	24129315
357	Methylation	PGPGGRGRGRGQGNW CCCCCCCCCCCCCCC	30.21	24129315
357	Dimethylation	PGPGGRGRGRGQGNW CCCCCCCCCCCCCCC	30.21	-
359	Methylation	PGGRGRGRGQGNWNM CCCCCCCCCCCCCCC	32.66	24129315
359	Dimethylation	PGGRGRGRGQGNWNM CCCCCCCCCCCCCCC	32.66	-
384	Phosphorylation	FIVPTGKTGLIIGKG EEEECCCCEEEECCC	38.27	25777480
394	Phosphorylation	IIGKGGETIKSISQQ EECCCCHHHHHHHHH	36.66	25777480
396	Ubiquitination	GKGGETIKSISQQSG CCCCHHHHHHHHHCC	49.51	-
397	Phosphorylation	KGGETIKSISQQSGA CCCHHHHHHHHHCCC	24.50	25777480
399	Phosphorylation	GETIKSISQQSGARI CHHHHHHHHHCCCEE	29.29	25777480
402	Phosphorylation	IKSISQQSGARIELQ HHHHHHHCCCEEEEE	27.12	25777480
411	Phosphorylation	ARIELQRSPPPNADP CEEEEECCCCCCCCC	28.88	26824392
428	Phosphorylation	KLFTIRGTPQQIDYA EEEEECCCHHHHHHH	14.21	-
622	Phosphorylation	YRQQAAYYAQTSPQG HHHHHHHHHCCCCCC	6.36	28285833
625	Phosphorylation	QAAYYAQTSPQGMPQ HHHHHHCCCCCCCCC	33.91	23984901
626	Phosphorylation	AAYYAQTSPQGMPQH HHHHHCCCCCCCCCC	11.80	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUBP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUBP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUBP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FUBP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.