| UniProt ID | CO4B_MOUSE | |
|---|---|---|
| UniProt AC | P01029 | |
| Protein Name | Complement C4-B | |
| Gene Name | C4b | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 1738 | |
| Subcellular Localization | Secreted . Cell junction, synapse . Cell projection, axon . Cell projection, dendrite . | |
| Protein Description | Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (By similarity).. | |
| Protein Sequence | MRLLWGLAWVFSFCASSLQKPRLLLFSPSVVNLGTPLSVGVQLLDAPPGQEVKGSVFLRNPKGGSCSPKKDFKLSSGDDFVLLSLEVPLEDVRSCGLFDLRRAPHIQLVAQSPWLRNTAFKATETQGVNLLFSSRRGHIFVQTDQPIYNPGQRVRYRVFALDQKMRPSTDFLTITVENSHGLRVLKKEIFTSTSIFQDAFTIPDISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKITPWKPYILMVPSNSDEIQLDIQARYIYGKPVQGVAYTRFALMDEQGKRTFLRGLETQAKLVEGRTHISISKDQFQAALDKINIGVRDLEGLRLYAATAVIESPGGEMEEAELTSWRFVSSAFSLDLSRTKRHLVPGAHFLLQALVQEMSGSEASNVPVKVSATLVSGSDSQVLDIQQSTNGIGQVSISFPIPPTVTELRLLVSAGSLYPAIARLTVQAPPSRGTGFLSIEPLDPRSPSVGDTFILNLQPVGIPAPTFSHYYYMIISRGQIMAMGREPRKTVTSVSVLVDHQLAPSFYFVAYFYHQGHPVANSLLINIQSRDCEGKLQLKVDGAKEYRNADMMKLRIQTDSKALVALGAVDMALYAVGGRSHKPLDMSKVFEVINSYNVGCGPGGGDDALQVFQDAGLAFSDGDRLTQTREDLSCPKEKKSRQKRNVNFQKAVSEKLGQYSSPDAKRCCQDGMTKLPMKRTCEQRAARVPQQACREPFLSCCKFAEDLRRNQTRSQAHLARNNHNMLQEEDLIDEDDILVRTSFPENWLWRVEPVDSSKLLTVWLPDSMTTWEIHGVSLSKSKGLCVAKPTRVRVFRKFHLHLRLPISIRRFEQFELRPVLYNYLNDDVAVSVHVTPVEGLCLAGGGMMAQQVTVPAGSARPVAFSVVPTAAANVPLKVVARGVFDLGDAVSKILQIEKEGAIHREELVYNLDPLNNLGRTLEIPGSSDPNIVPDGDFSSLVRVTASEPLETMGSEGALSPGGVASLLRLPQGCAEQTMIYLAPTLTASNYLDRTEQWSKLSPETKDHAVDLIQKGYMRIQQFRKNDGSFGAWLHRDSSTWLTAFVLKILSLAQEQVGNSPEKLQETASWLLAQQLGDGSFHDPCPVIHRAMQGGLVGSDETVALTAFVVIALHHGLDVFQDDDAKQLKNRVEASITKANSFLGQKASAGLLGAHAAAITAYALTLTKASEDLRNVAHNSLMAMAEETGEHLYWGLVLGSQDKVVLRPTAPRSPTEPVPQAPALWIETTAYALLHLLLREGKGKMADKAASWLTHQGSFHGAFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGLKTHGLHLNNHQVKGLEEELKFSLGSTISVKVEGNSKGTLKILRTYNVLDMKNTTCQDLQIEVKVTGAVEYAWDANEDYEDYYDMPAADDPSVPLQPVTPLQLFEGRRSRRRREAPKVVEEQESRVQYTVCIWRNGKLGLSGMAIADITLLSGFHALRADLEKLTSLSDRYVSHFETDGPHVLLYFDSVPTTRECVGFGASQEVVVGLVQPSSAVLYDYYSPDHKCSVFYAAPTKSQLLATLCSGDVCQCAEGKCPRLLRSLERRVEDKDGYRMRFACYYPRVEYGFTVKVLREDGRAAFRLFESKITQVLHFRKDTMASIGQTRNFLSRASCRLRLEPNKEYLIMGMDGETSDNKGDPQYLLDSNTWIEEMPSEQMCKSTRHRAACFQLKDFLMEFSSRGCQV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 224 | N-linked_Glycosylation | FSDGLESNRSTHFEV ECCCCCCCCCCCEEE | 32.33 | - | |
| 272 | Ubiquitination | QARYIYGKPVQGVAY EHHHHCCCCCCCEEE | 25.66 | - | |
| 302 | Ubiquitination | RGLETQAKLVEGRTH HHHHHHHHHHCCCCE | 43.16 | - | |
| 314 | Ubiquitination | RTHISISKDQFQAAL CCEEEECHHHHHHHH | 54.61 | - | |
| 323 | Ubiquitination | QFQAALDKINIGVRD HHHHHHHHCCCCCCC | 38.20 | - | |
| 451 | Phosphorylation | LVSAGSLYPAIARLT HHHHCCHHHEEEEEE | 7.72 | - | |
| 683 | Ubiquitination | KRNVNFQKAVSEKLG HHCCCHHHHHHHHHC | 46.77 | - | |
| 688 | Ubiquitination | FQKAVSEKLGQYSSP HHHHHHHHHCCCCCC | 50.87 | - | |
| 743 | N-linked_Glycosylation | FAEDLRRNQTRSQAH HHHHHHHCHHHHHHH | 40.93 | - | |
| 810 | Phosphorylation | TWEIHGVSLSKSKGL CEEEEEEEECCCCCE | 31.36 | 22324799 | |
| 812 | Phosphorylation | EIHGVSLSKSKGLCV EEEEEEECCCCCEEE | 27.63 | 22324799 | |
| 818 | S-palmitoylation | LSKSKGLCVAKPTRV ECCCCCEEEECCCEE | 3.69 | 26165157 | |
| 910 | Ubiquitination | AAANVPLKVVARGVF CCCCCCCEEEEEEEC | 28.70 | - | |
| 925 | Ubiquitination | DLGDAVSKILQIEKE CHHHHHHHHHHHHHC | 40.62 | - | |
| 1034 | Phosphorylation | TEQWSKLSPETKDHA HHHHHHCCHHHHHHH | 25.15 | 23737553 | |
| 1192 | Phosphorylation | GAHAAAITAYALTLT HHHHHHHHHHHHHHH | 14.64 | - | |
| 1194 | Phosphorylation | HAAAITAYALTLTKA HHHHHHHHHHHHHHC | 8.09 | - | |
| 1315 | Phosphorylation | LSAYWIASHTTEEKA HHHHHHHCCCCCHHH | 16.54 | - | |
| 1324 | N-linked_Glycosylation | TTEEKALNVTLSSMG CCCHHHHCEEHHHCC | 29.59 | 17330941 | |
| 1387 | N-linked_Glycosylation | YNVLDMKNTTCQDLQ EEEEECCCCCCCCEE | 33.70 | - | |
| 1413 | Sulfation | AWDANEDYEDYYDMP EEECCCCCHHHCCCC | 12.43 | - | |
| 1413 | Sulfation | AWDANEDYEDYYDMP EEECCCCCHHHCCCC | 12.43 | - | |
| 1416 | Sulfation | ANEDYEDYYDMPAAD CCCCCHHHCCCCCCC | 6.88 | - | |
| 1416 | Sulfation | ANEDYEDYYDMPAAD CCCCCHHHCCCCCCC | 6.88 | - | |
| 1417 | Sulfation | NEDYEDYYDMPAADD CCCCHHHCCCCCCCC | 20.35 | - | |
| 1417 | Sulfation | NEDYEDYYDMPAADD CCCCHHHCCCCCCCC | 20.35 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CO4B_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CO4B_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CO4B_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of CO4B_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."; Bernhard O.K., Kapp E.A., Simpson R.J.; J. Proteome Res. 6:987-995(2007). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1324, AND MASSSPECTROMETRY. | |
