FARP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FARP1_MOUSE
• UniProt AC: F8VPU2
• Protein Name: FERM, ARHGEF and pleckstrin domain-containing protein 1
• Gene Name: Farp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1048
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . Cell junction, synapse, synaptosome. Cytoplasm, cytosol. Cell projection, filopodium. Cell projection, dendrite. Cell projection, dendritic spine. Recruited to
• Protein Description: Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity)..
• Protein Sequence: MGEIEQKPTPASRLGAPENSGISTLERGQKPPPTPSGKLMTVKIQMLDDTQEAFEVPQRAPGKVLFDAVCNHLNLVEGDYFGLEFPDHRKIVVWLDLLKPIVKQIRRPKHVVVKFVVKFFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHLAKNKYVPQQDALEDRIMEFHHSHVGQTPAESDFQLLEVARRLEMYGIRLHPAKDREGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDVNSSYQDTLEFLMAGRDFCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQFERKHSKIHSTRSLVSQPTAPNSEVPKQSPQSASLTFGEGTESPGGQSCQQAKETKACTLELGPHQSPALPKSPPGSKAADGTTVVPPEEEEEEEGGKDGIRPSNPQPPQPSTGSLTGSPHLSELSINSQGGAAPANVTLSPNLSPDNKQASPLISPLLNDQACPRTDDEEEGRRKRFPTDKAYYIAKEVSTTERTYLKDLEVIASWFQSTVSKEDSMPEALKSLIFPNFEPLHKFHTNFLKEIEQRLALWEGRSNAHVRGDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALETSIKGSRRLEHFCRDFELQKVCYLPLNTFLLRPLHRLMHYKHVLERLCKHHPPNHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVTPGREFIRLGSLSKLSGKGLQQRMFFLFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEEEWGVPHCLTLRGQRQSIIVAASSRSEMEKWMEDIQMAIDLAEKSNGPTPELLASSPPDNKSPDEATAADQESEDDLSASRTSLERQAPHRGNTMVHVCWHRSTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDSHPLASLPLLGYSLTIPSESENIHKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATSSASRAHILSHKESHLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	GEIEQKPTPASRLGA CCCCCCCCCHHHCCC		20469934
12	Phosphorylation	EQKPTPASRLGAPEN CCCCCCHHHCCCCCC		26824392
20	Phosphorylation	RLGAPENSGISTLER HCCCCCCCCCCCCCC		26824392
23	Phosphorylation	APENSGISTLERGQK CCCCCCCCCCCCCCC		25521595
24	Phosphorylation	PENSGISTLERGQKP CCCCCCCCCCCCCCC		25521595
34	Phosphorylation	RGQKPPPTPSGKLMT CCCCCCCCCCCCEEE		26824392
36	Phosphorylation	QKPPPTPSGKLMTVK CCCCCCCCCCEEEEE		29550500
141	Ubiquitination	YLFALQVKQDLAQGR HHHHHHHHHHHHCCC		22790023
335	Phosphorylation	PVLFSRGSSFRFSGR CEEEECCCCCCCCCC		21743459
336	Phosphorylation	VLFSRGSSFRFSGRT EEEECCCCCCCCCCC		25263469
340	Phosphorylation	RGSSFRFSGRTQKQV CCCCCCCCCCCHHHH		25263469
345	Ubiquitination	RFSGRTQKQVLDYVK CCCCCCHHHHHHHHH		-
350	Phosphorylation	TQKQVLDYVKEGGHK CHHHHHHHHHHCCCE		22807455
352	Ubiquitination	KQVLDYVKEGGHKKV HHHHHHHHHCCCEEE		-
366	Phosphorylation	VQFERKHSKIHSTRS EEHHHCCCCCCCCCH		21454597
370	Phosphorylation	RKHSKIHSTRSLVSQ HCCCCCCCCCHHHCC		26239621
371	Phosphorylation	KHSKIHSTRSLVSQP CCCCCCCCCHHHCCC		30352176
373	Phosphorylation	SKIHSTRSLVSQPTA CCCCCCCHHHCCCCC		26824392
376	Phosphorylation	HSTRSLVSQPTAPNS CCCCHHHCCCCCCCC		29899451
379	Phosphorylation	RSLVSQPTAPNSEVP CHHHCCCCCCCCCCC		21183079
383	Phosphorylation	SQPTAPNSEVPKQSP CCCCCCCCCCCCCCC		21183079
389	Phosphorylation	NSEVPKQSPQSASLT CCCCCCCCCCCCEEE		22817900
392	Phosphorylation	VPKQSPQSASLTFGE CCCCCCCCCEEEECC		22817900
394	Phosphorylation	KQSPQSASLTFGEGT CCCCCCCEEEECCCC		27087446
396	Phosphorylation	SPQSASLTFGEGTES CCCCCEEEECCCCCC		21183079
401	Phosphorylation	SLTFGEGTESPGGQS EEEECCCCCCCCCCC		21183079
403	Phosphorylation	TFGEGTESPGGQSCQ EECCCCCCCCCCCHH		27087446
408	Phosphorylation	TESPGGQSCQQAKET CCCCCCCCHHHHHHC		29899451
419	Phosphorylation	AKETKACTLELGPHQ HHHCCCCEEECCCCC		26239621
427	Phosphorylation	LELGPHQSPALPKSP EECCCCCCCCCCCCC		27087446
433	Phosphorylation	QSPALPKSPPGSKAA CCCCCCCCCCCCCCC		21930439
437	Phosphorylation	LPKSPPGSKAADGTT CCCCCCCCCCCCCCE		22324799
472	Phosphorylation	NPQPPQPSTGSLTGS CCCCCCCCCCCCCCC		25338131
473	Phosphorylation	PQPPQPSTGSLTGSP CCCCCCCCCCCCCCC		25338131
475	Phosphorylation	PPQPSTGSLTGSPHL CCCCCCCCCCCCCCH		25338131
477	Phosphorylation	QPSTGSLTGSPHLSE CCCCCCCCCCCCHHH		25338131
479	Phosphorylation	STGSLTGSPHLSELS CCCCCCCCCCHHHEE		25338131
505	Phosphorylation	VTLSPNLSPDNKQAS EEECCCCCCCCCCCC		29514104
512	Phosphorylation	SPDNKQASPLISPLL CCCCCCCCCCHHHHC		27087446
516	Phosphorylation	KQASPLISPLLNDQA CCCCCCHHHHCCCCC		27087446
527	Phosphorylation	NDQACPRTDDEEEGR CCCCCCCCCCCCCHH		26824392
548	Ubiquitination	DKAYYIAKEVSTTER CHHHHHHEECCCCCC		22790023
602	Ubiquitination	KFHTNFLKEIEQRLA HHHHHHHHHHHHHHH		22790023
615	Phosphorylation	LALWEGRSNAHVRGD HHHHCCCCCCHHCCC		26824392
623	Phosphorylation	NAHVRGDYQRIGDVM CCHHCCCHHHHHHHH		29514104
632	Ubiquitination	RIGDVMLKNIQGMKH HHHHHHHHHHCCHHH		22790023
657	Phosphorylation	ALEALETSIKGSRRL HHHHHHHHHHHHHHH		29514104
659	Ubiquitination	EALETSIKGSRRLEH HHHHHHHHHHHHHHH		22790023
661	Phosphorylation	LETSIKGSRRLEHFC HHHHHHHHHHHHHHH		29514104
696	Ubiquitination	LHRLMHYKHVLERLC HHHHHHHHHHHHHHH		22790023
748	Ubiquitination	QKLHELKKDLIGIDN HHHHHHHHHHCCCCC		22790023
771	Ubiquitination	IRLGSLSKLSGKGLQ HHCCCHHHHCCCCHH		22790023
773	Phosphorylation	LGSLSKLSGKGLQQR CCCHHHHCCCCHHHH		29514104
836	Phosphorylation	TLRGQRQSIIVAASS EECCCCEEEEEEECC		26239621
842	Phosphorylation	QSIIVAASSRSEMEK EEEEEEECCHHHHHH		25266776
843	Phosphorylation	SIIVAASSRSEMEKW EEEEEECCHHHHHHH		25266776
864	Phosphorylation	AIDLAEKSNGPTPEL HHHHHHHHCCCCHHH		27087446
868	Phosphorylation	AEKSNGPTPELLASS HHHHCCCCHHHHCCC		18846507
874	Phosphorylation	PTPELLASSPPDNKS CCHHHHCCCCCCCCC		24068923
875	Phosphorylation	TPELLASSPPDNKSP CHHHHCCCCCCCCCH		27087446
881	Phosphorylation	SSPPDNKSPDEATAA CCCCCCCCHHHCCCC		22324799
886	Phosphorylation	NKSPDEATAADQESE CCCHHHCCCCCCCCH		27742792
892	Phosphorylation	ATAADQESEDDLSAS CCCCCCCCHHHHHHC		27087446
897	Phosphorylation	QESEDDLSASRTSLE CCCHHHHHHCHHHHH		27087446
899	Phosphorylation	SEDDLSASRTSLERQ CHHHHHHCHHHHHHH		27087446
901	Phosphorylation	DDLSASRTSLERQAP HHHHHCHHHHHHHCC		27087446
902	Phosphorylation	DLSASRTSLERQAPH HHHHCHHHHHHHCCC		27087446
924	Phosphorylation	VCWHRSTSVSMVDFS EEEECCCCCEEEEEE		23567750
926	Phosphorylation	WHRSTSVSMVDFSIA EECCCCCEEEEEEHH		23567750
931	Phosphorylation	SVSMVDFSIAVENQL CCEEEEEEHHEECCC		23567750
939	Phosphorylation	IAVENQLSGNLLRKF HHEECCCCCCHHHHH		23567750
947	Acetylation	GNLLRKFKNSNGWQK CCHHHHHHCCCCHHH		7618811
1007	Phosphorylation	VFKLHFKSHVYYFRA EEEEEECEEEEEEEE		25338131
1041	Phosphorylation	ASRAHILSHKESHLY HHHHHHHHCCHHHCC		27841257
1045	Phosphorylation	HILSHKESHLY---- HHHHCCHHHCC----		29514104
1048	Phosphorylation	SHKESHLY------- HCCHHHCC-------		29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FARP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FARP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FARP1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of FARP1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.