dbPTM

DSE_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DSE_MOUSE
UniProt AC	Q8BLI4
Protein Name	Dermatan-sulfate epimerase
Gene Name	Dse
Organism	Mus musculus (Mouse).
Sequence Length	958
Subcellular Localization	Membrane Multi-pass membrane protein .
Protein Description	Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues..
Protein Sequence	MRTHTRGAPSVFFICLLCCVSAFITDENPEVMIPFTNANYDSHPMLYFSRKDVAELQLRAASSHEHIAARLTEAVHTMLTNPLEYLPPWDPKEYSARWNEIYGNNLGALAMFCVLYPENTEARDMAKDYMERMAAQPSWLVKDAPWDEVPLAHSLVGFATAYDFLYNYLSKTQQETFLEVIANASGYMYETSYRRGWGFQYLHNHQPTNCMALLTGSLILMNQGYLQEAYLWTKQVLSIMEKSLVLLREVTDGSLYEGVAYGSYTTRSLFQYMFLVQRHFDINHFGHPWLKQHFAFMYRTILPGFQRTVAIADSNYNWFYGPESQLVFLDKFVMRNGSGNWLADQIRRNRVVEGPGTPSKGQRWCTLHTEFLWYDASLKPVPPPDFGTPTLHYFEDWGVVTYGSALPAEINRSFLSFKSGKLGGRAIYDIVHRNKYKDWIKGWRNFNAGHEHPDQNSFTFAPNGVPFITEALYGPKYTYFNNVLMFSPAVSKSCFSPWEGQVTEDCSSKWSKYKHDLAASCQGRVIAADEKDGVVFIRGEGVGAYNPMLNLKHIQRNLILLHPQLLLLVDQIHLGEESPLETAASFFHNVDVPFEETVVDGVHGALIRQRDGLYKMYWMDDTGYSEKANFASVMYPRGYPYNGTNYVNVTMHLRSPITRAAYLFIGPSVDVQSFSIHGDPQRLDVFIATSEHAYATYLWTGENTGHSAFAQVIADHQKILFDQSSAIKSTAVPEVKDYAAIVEQNLQHFKPVFQLLEKQILSRVQNTASFRKTAERLLRFSDKRQTEEAIDRIFAISQQQRQQRGKSKKSRKAGKHYKFVDAVPDIFAQIEVNEKKIRQKAQVLAQREQPIDEDEEMKDLLDFADVTYEKHKNEGSVKGGFGQVRMVTSHNRAPSLSASYTRLFLILNIAIFFVMLAMQLTYFQRAQSLHGQRCLYAVLLIDSCVLLWLYSSCSQSQC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
545	Phosphorylation	RGEGVGAYNPMLNLK ECCCCCCCCCCCCHH	17.55	28059163
642	N-linked_Glycosylation	YPRGYPYNGTNYVNV CCCCCCCCCCCCEEE	46.43	-
724	Phosphorylation	QKILFDQSSAIKSTA CCEEECCCHHHCCCC	24.47	22871156
725	Phosphorylation	KILFDQSSAIKSTAV CEEECCCHHHCCCCC	28.51	22418434
786	Phosphorylation	RFSDKRQTEEAIDRI CCCCHHHHHHHHHHH	39.56	26824392
797	Phosphorylation	IDRIFAISQQQRQQR HHHHHHHHHHHHHHH	20.64	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DSE_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DSE_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DSE_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DSE_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DSE_MOUSE

Related Literatures of Post-Translational Modification