PCAT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCAT1_MOUSE
• UniProt AC: Q3TFD2
• Protein Name: Lysophosphatidylcholine acyltransferase 1
• Gene Name: Lpcat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 534
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Lipid droplet . May adopt a monotopic topology when embedded in the lipid monolayer of the lipid droplet, with b
• Protein Description: Possesses both acyltransferase and acetyltransferase activities. [PubMed: 16704971 Activity is calcium-independent]
• Protein Sequence: MRLRGRGPRAAPSSSSGAGDARRLAPPGRNPFVHELRLSALQKAQVAFMTLTLFPIRLLFAAFMMLLAWPFALLASLGPPDKEPEQPLALWRKVVDFLLKAIMRTMWFAGGFHRVAVKGRQALPTEAAILTLAPHSSYFDAIPVTMTMSSIVMKAESRDIPIWGTLIRYIRPVFVSRSDQDSRRKTVEEIKRRAQSNGKWPQIMIFPEGTCTNRTCLITFKPGAFIPGVPVQPVVLRYPNKLDTITWTWQGPGALKILWLTLCQFQNQVEIEFLPVYCPSEEEKRNPALYASNVRRVMAKALGVSVTDYTFEDCQLALAEGQLRLPADTCLLEFARLVRGLGLKPENLEKDLDKYSESARMKRGEKIRLPEFAAYLEVPVSDALEDMFSLFDESGGGEIDLREYVVALSVVCRPSQTLATIQLAFKMYGSPEDGSIDEANLSCILKTALGVSELTVTDLFQAIDQEDKGRITFDDFCGFAEMYPDYAEDYLYPDQTHFDSCAQTPPAPTPNGFCIDFSPENSDFGRKNSCKKAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
50	Phosphorylation	KAQVAFMTLTLFPIR HHHHHHHHHHHHHHH	15.33	29233185
105	Phosphorylation	LLKAIMRTMWFAGGF HHHHHHHHHHHHCCC	11.02	29899451
178	Phosphorylation	RPVFVSRSDQDSRRK HHEECCCCCHHHHHH	31.92	21068446
182	Phosphorylation	VSRSDQDSRRKTVEE CCCCCHHHHHHHHHH	28.49	21068446
221	Ubiquitination	RTCLITFKPGAFIPG CEEEEEECCCCCCCC	33.61	-
355	Phosphorylation	LEKDLDKYSESARMK HHHHHHHHHHHHHHH	19.82	-
472	Phosphorylation	QEDKGRITFDDFCGF CHHCCCCCHHCCCCH	21.46	22871156
529	Phosphorylation	SDFGRKNSCKKAD-- CCCCCCCCCCCCC--	30.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
178	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
178	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
182	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
182	S	Phosphorylation	Kinase	GSK3B	Q9WV60	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	Btrc	Q3ULA2	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCAT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCAT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCAT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.