DSC3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DSC3_MOUSE
• UniProt AC: P55850
• Protein Name: Desmocollin-3
• Gene Name: Dsc3
• Organism: Mus musculus (Mouse).
• Sequence Length: 896
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Cell junction, desmosome.
• Protein Description: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms..
• Protein Sequence: MVVPEFRSPQCRALCTKLLLTLWVFSFVGEACKKVTFHVPSTLEADKIIGRVSLKECLSSADGIMPSDPDFRVLDDGSVYPTRAVVLSDEKRSFTIQLSDSKMQTQKEIPVILEHKKKVLKKRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTVFYSISGRGADQEPLNWFFIERDTGNLYCTRPVDREEYDVFDLIAYASTADGYSADLPLPLPIKIEDENDNYPLFTEAIYAFEVPEGSRLGTVVGTVCATDKDEPDTMHTRLKYSILEQTPPSPGLFSVHPDTGVITTVSHYMDREVVDKYKLIMKVQDMNGQFFGLISTSTCIITVQDSNDNAPTFRQNTYETAVEENTYNVEILRIPVDDKDMINTANWKANFTILKGNENGWFKITTDPVTNEGVLCVVKPLDYEENRQVTLEIGVNNEAPFIKDVANRIPTMNRAMVTVHVKDQNEGPECKPPEQYVRIKENSAVGSKINGYKAYDPETKNSNGLRYKKLQDPKDWVSIEEVSGLLTISKTLDREIMAPRNDMYNITVMAIDQEGKSCTGTLAVNIEDVNDNAPEIIQDYIVICKPKMGYTDISAVDPDEPIHGPPFQFNLANTSPEVNRIWTLNQVNDTAARLSYQKTADVQIYNVPVTVKDRAGQSATKILRVNLCDCTHPSQCPLRSRSAGITLGKWAILAILLGIALLFSVLLTLVCGVVTARKGKHFPEDLAQQNLIISNTEAPGDDRVCSANGFTTHTANNSSQGFCGTMGSGMRNGGQETIEMMKGHQTLDSCRVAGHHHTLDSGRGGHMDTDNCRYTYSEWHSFTQPRLGEKLHVCNQNEDHIPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEEGLDFLNNLEPKFLTLAETCTKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
166	N-linked_Glycosylation	VQSDAAQNYTVFYSI HHHCHHCCEEEEEEE	29.71	-
386	Phosphorylation	DDKDMINTANWKANF CCHHHCCCCCEEEEE	15.50	-
392	N-linked_Glycosylation	NTANWKANFTILKGN CCCCEEEEEEEEECC	30.76	-
547	N-linked_Glycosylation	APRNDMYNITVMAID CCCCCCEEEEEEEEC	19.47	-
630	N-linked_Glycosylation	IWTLNQVNDTAARLS EEEEHHCCCHHHHHH	31.02	16170054
787	Phosphorylation	IEMMKGHQTLDSCRV HHHHHCCCCHHHCEE	27.19	19367708
788	Phosphorylation	EMMKGHQTLDSCRVA HHHHCCCCHHHCEEC	3.52	19367708
790	Phosphorylation	MKGHQTLDSCRVAGH HHCCCCHHHCEECCC	13.61	19367708
791	Phosphorylation	KGHQTLDSCRVAGHH HCCCCHHHCEECCCC	3.96	19367708
800	Phosphorylation	RVAGHHHTLDSGRGG EECCCCCCCCCCCCC	4.24	28507225
803	Phosphorylation	GHHHTLDSGRGGHMD CCCCCCCCCCCCCCC	31.73	28507225
823	Phosphorylation	YTYSEWHSFTQPRLG EEHHHHHCCCCCCCC	4.81	28507225
833 (in isoform 2)	Phosphorylation	-	32.90	19367708
858	Phosphorylation	TYNYEGRGSPAGSVG EEEECCCCCCCCCCC	15.37	19367708
859	Phosphorylation	YNYEGRGSPAGSVGC EEECCCCCCCCCCCC	43.39	19367708
862	Phosphorylation	EGRGSPAGSVGCCSE CCCCCCCCCCCCCCC	19.90	19367708
863	Phosphorylation	GRGSPAGSVGCCSEK CCCCCCCCCCCCCCC	7.14	19367708
867	Phosphorylation	PAGSVGCCSEKQEEE CCCCCCCCCCCCHHH	52.48	19367708
868	Phosphorylation	AGSVGCCSEKQEEEG CCCCCCCCCCCHHHC	44.86	19367708

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DSC3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DSC3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DSC3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of DSC3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"High throughput quantitative glycomics and glycoform-focusedproteomics of murine dermis and epidermis.";
Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K.,Monde K., Nishimura S.;
Mol. Cell. Proteomics 4:1977-1989(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-630, AND MASSSPECTROMETRY.
PubMed: 16170054

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-858; SER-862 ANDSER-867, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 (ISOFORM2), AND MASS SPECTROMETRY.
PubMed: 19367708