GCP60_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCP60_MOUSE
• UniProt AC: Q8BMP6
• Protein Name: Golgi resident protein GCP60
• Gene Name: Acbd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 525
• Subcellular Localization: Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Also mitochondrial (via its interaction with PBR).
• Protein Description: Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. [PubMed: 12711385 Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity]
• Protein Sequence: MAAQLNVEQLEVSLDGLTLSPDSEERPGAEGAPPQTPPSSAPGNGLGSGASGQQREPGEAAAEGAAEEARRMEQHWGFGLEELYGLALRFYKIKDGKAFHPTYEEKLKFVALHKQVLLGPYNPDTSPEVGFFDVLGNDRRREWAALGNMSKEDAMVEFVKLLNKCCPLLSAYVASHRIEKEEEEKRRKAEEERRQREEEERERLQKEEEKRKREKEDRLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQILIRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVMAGASLPASSKVNTAGASDTLSVNGQAKTHTENSEKVLEPEAAEEALENGPKDSLPVIAAPSMWTRPQIKDFKEKIRQDADSVITVRRGEVVTVRVPTHEEGSYLFWEFATDSYDIGFGVYFEWTDSPNAAVSVHVSESSDEEEEEEENVTCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKFDNSYSLWRSKSVYYRVYYTR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQLNVEQ ------CCCCCCHHH	12.15	-
13	Phosphorylation	NVEQLEVSLDGLTLS CHHHEEEEECCEEEC	16.03	23649490
18	Phosphorylation	EVSLDGLTLSPDSEE EEEECCEEECCCCCC	30.62	-
20	Phosphorylation	SLDGLTLSPDSEERP EECCEEECCCCCCCC	22.79	-
23	Phosphorylation	GLTLSPDSEERPGAE CEEECCCCCCCCCCC	44.75	23649490
39	Phosphorylation	APPQTPPSSAPGNGL CCCCCCCCCCCCCCC	40.09	23649490
40	Phosphorylation	PPQTPPSSAPGNGLG CCCCCCCCCCCCCCC	44.23	-
121	Phosphorylation	KQVLLGPYNPDTSPE CCEECCCCCCCCCCC	37.21	23984901
125	Phosphorylation	LGPYNPDTSPEVGFF CCCCCCCCCCCCCCE	47.65	26745281
126	Phosphorylation	GPYNPDTSPEVGFFD CCCCCCCCCCCCCEE	26.83	26745281
313	Phosphorylation	EVVMAGASLPASSKV HHHHCCCCCCCCCCC	33.69	29514104
326	Phosphorylation	KVNTAGASDTLSVNG CCCCCCCCCCEEECC	30.15	25619855
328	Phosphorylation	NTAGASDTLSVNGQA CCCCCCCCEEECCEE	20.59	25619855
330	Phosphorylation	AGASDTLSVNGQAKT CCCCCCEEECCEEEE	18.67	27087446
383	Ubiquitination	QIKDFKEKIRQDADS HHHHHHHHHHCCCCC	43.72	-
445	Phosphorylation	AAVSVHVSESSDEEE CEEEEEECCCCCCHH	19.51	51457729
447	Phosphorylation	VSVHVSESSDEEEEE EEEEECCCCCCHHHH	35.27	19060867
448	Phosphorylation	SVHVSESSDEEEEEE EEEECCCCCCHHHHH	45.02	51457745
484	S-nitrosocysteine	VPVYRRDCHEEVYAG HHHECCCCCCCCCCC	4.06	-
484	S-nitrosylation	VPVYRRDCHEEVYAG HHHECCCCCCCCCCC	4.06	21278135
489	Phosphorylation	RDCHEEVYAGSHQYP CCCCCCCCCCCCCCC	14.44	22817900
504	Ubiquitination	GRGVYLLKFDNSYSL CCEEEEEEECCCEEE	48.34	-
510	Phosphorylation	LKFDNSYSLWRSKSV EEECCCEEEEEECEE	22.67	51457737

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCP60_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCP60_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCP60_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GCP60_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.