LONM_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LONM_MOUSE
• UniProt AC: Q8CGK3
• Protein Name: Lon protease homolog, mitochondrial {ECO:0000255|HAMAP-Rule:MF_03120}
• Gene Name: Lonp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 949
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters..
• Protein Sequence: MAASTGYVRLWAAARCWVLRRPLLAVTGGRVPSASGSWLRRGCRACDMSAPWGGRVLPGGVQWRGLWDSGNRGGSDETSEGGAEDGATASTGEGPVVTALAPMTVPDVFPHLPLIAITRNPVFPRFIKIVEVKNKKLVELLRRKVRLAQPYVGVFLKRDDNNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVTGHRRIHISRQLEVEPEGLEPEAEKQKSRRKLKRGKKEVEDELGPKPQLEMVTEAATDTSKEVLMVEVENVAHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNILKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLRELVVPKHVMDVVDEELSKLALLDNHSSEFNVTRNYLDWLTSIPWGRQSDENLDLARAQAVLEEDHYGMEDVKKRVLEFIAVSQLRGSTQGKILCFHGPPGVGKTSIARSIARALGREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLVLIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVIDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARTLCGLDESKAQLSAAVLTLLIKQYCRESGVRNLQKQVEKVLRKAAYKIVSGEAQTVQVTPENLQDFVGKPVFTVERMYEVTPPGVVMGLAWTAMGGSTLFVETSLRRPQPSGSKEDKDGSLEVTGQLGDVMKESARIAYTYARAFLMEQDPENDFLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLALGQPVLQNLAMTGEVSLTGKVLPVGGIKEKTIAAKRAGVTCIILPAENRKDYSDLAPFITEGLEVHFVEHYRDIFPIAFPRREHREALAVER

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
78	Phosphorylation	NRGGSDETSEGGAED CCCCCCCCCCCCCCC	36.75	23140645
79	Phosphorylation	RGGSDETSEGGAEDG CCCCCCCCCCCCCCC	32.00	23140645
88	Phosphorylation	GGAEDGATASTGEGP CCCCCCCCCCCCCCC	27.03	23140645
90	Phosphorylation	AEDGATASTGEGPVV CCCCCCCCCCCCCEE	32.37	23140645
91	Phosphorylation	EDGATASTGEGPVVT CCCCCCCCCCCCEEE	36.47	23140645
98	Phosphorylation	TGEGPVVTALAPMTV CCCCCEEEEECCCCC	19.04	23140645
191	Acetylation	EMQDLGDKLRMIVTG HHHHHHHHEEEHHHC	35.87	23954790
221	Acetylation	GLEPEAEKQKSRRKL CCCHHHHHHHHHHHH	70.81	23201123
242	Acetylation	VEDELGPKPQLEMVT HHHHCCCCCCEEHHH	43.53	23954790
287	Acetylation	ALTAEIVKTIRDIIA HHHHHHHHHHHHHHH	43.85	23954790
346	Acetylation	LEETNILKRLYKALS HHHHHHHHHHHHHHH	36.24	23954790
356	Succinylation	YKALSLLKKEFELSK HHHHHHHHHHHHHHH	56.39	23954790
363	Succinylation	KKEFELSKLQQRLGR HHHHHHHHHHHHHHH	64.04	23806337
363	Acetylation	KKEFELSKLQQRLGR HHHHHHHHHHHHHHH	64.04	23954790
375	Acetylation	LGREVEEKIKQTHRK HHHHHHHHHHHHHHH	41.52	23201123
382	Acetylation	KIKQTHRKYLLQEQL HHHHHHHHHHHHHHH	32.42	23576753
383	Phosphorylation	IKQTHRKYLLQEQLK HHHHHHHHHHHHHHH	16.77	-
400	Acetylation	KKELGLEKDDKDAIE HHHHCCCCCCHHHHH	76.03	23864654
403	Acetylation	LGLEKDDKDAIEEKF HCCCCCCHHHHHHHH	60.23	23954790
409	Acetylation	DKDAIEEKFRERLRE CHHHHHHHHHHHHHH	36.61	23864654
432	Phosphorylation	DVVDEELSKLALLDN HHHCHHHHHHHHHCC	28.98	-
463	Phosphorylation	SIPWGRQSDENLDLA HCCCCCCCCCCHHHH	45.60	26643407
509	Glutathionylation	STQGKILCFHGPPGV CCCCCEEEEECCCCC	2.42	24333276
524	Phosphorylation	GKTSIARSIARALGR CHHHHHHHHHHHHCC	16.16	25338131
626	Glutathionylation	LSKVLFICTANVIDT HHHHHHHHCCCHHHC	2.00	24333276
707	Acetylation	NLQKQVEKVLRKAAY HHHHHHHHHHHHHHH	47.95	23201123
737	Acetylation	NLQDFVGKPVFTVER HHHHHCCCCCEEEEE	32.48	23954790
737	Succinylation	NLQDFVGKPVFTVER HHHHHCCCCCEEEEE	32.48	23954790
785	Acetylation	PSGSKEDKDGSLEVT CCCCCCCCCCCEEEE	66.15	23954790
898	S-palmitoylation	AKRAGVTCIILPAEN HHHCCCEEEEEECCC	1.37	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LONM_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LONM_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LONM_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LONM_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.