| UniProt ID | PERM_MOUSE | |
|---|---|---|
| UniProt AC | P11247 | |
| Protein Name | Myeloperoxidase | |
| Gene Name | Mpo | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 718 | |
| Subcellular Localization | Lysosome. | |
| Protein Description | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.. | |
| Protein Sequence | MKLLLALAGLLAPLAMLQTSNGATPALLGEVENSVVLSCMEEAKQLVDRAYKERRESIKRSLQSGSASPTELLFYFKQPVAGTRTAVRAADYLHVALDLLKRKLQPLWPRPFNVTDVLTPAQLNLLSVSSGCAYQDVRVTCPPNDKYRTITGHCNNRRSPTLGASNRAFVRWLPAEYEDGVSMPFGWTPGVNRNGFKVPLARQVSNAIVRFPNDQLTKDQERALMFMQWGQFLDHDITLTPEPATRFSFFTGLNCETSCLQQPPCFPLKIPPNDPRIKNQKDCIPFFRSCPACTRNNITIRNQINALTSFVDASGVYGSEDPLARKLRNLTNQLGLLAINTRFQDNGRALMPFDSLHDDPCLLTNRSARIPCFLAGDMRSSEMPELTSMHTLFVREHNRLATQLKRLNPRWNGEKLYQEARKIVGAMVQIITYRDYLPLVLGPAAMKKYLPQYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLNNQYRPTGPNPRVPLSKVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIVVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPSTVGELGTVLKNLELARKLMAQYGTPNNIDIWMGGVSEPLEPNGRVGQLLACLIGTQFRKLRDGDRFWWENPGVFSKQQRQALASISLPRIICDNTGITTVSKNNIFMSNTYPRDFVSCNTLPKLNLTSWKET | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 66 | Phosphorylation | KRSLQSGSASPTELL HHHHHCCCCCCCEEE | 30.71 | 28973931 | |
| 68 | Phosphorylation | SLQSGSASPTELLFY HHHCCCCCCCEEEEE | 33.77 | 28973931 | |
| 75 | Phosphorylation | SPTELLFYFKQPVAG CCCEEEEEECCCCCC | 15.16 | 28973931 | |
| 113 | N-linked_Glycosylation | PLWPRPFNVTDVLTP CCCCCCCCHHCCCCH | 38.16 | - | |
| 205 | Phosphorylation | VPLARQVSNAIVRFP CCCHHHHHHCEEECC | 16.53 | 25338131 | |
| 289 | Phosphorylation | DCIPFFRSCPACTRN CCCHHHHCCCCCCCC | 21.21 | - | |
| 290 | Oxidation | CIPFFRSCPACTRNN CCHHHHCCCCCCCCC | 1.84 | - | |
| 290 | Cysteine sulfenic acid (-SOH) | CIPFFRSCPACTRNN CCHHHHCCCCCCCCC | 1.84 | - | |
| 294 | Phosphorylation | FRSCPACTRNNITIR HHCCCCCCCCCEEHH | 38.24 | - | |
| 297 | N-linked_Glycosylation | CPACTRNNITIRNQI CCCCCCCCEEHHHHH | 29.50 | - | |
| 329 | N-linked_Glycosylation | PLARKLRNLTNQLGL HHHHHHHHHHHHHCC | 62.75 | - | |
| 355 | Phosphorylation | RALMPFDSLHDDPCL EECCCCCCCCCCCEE | 28.16 | - | |
| 364 | Phosphorylation | HDDPCLLTNRSARIP CCCCEECCCCCCCCC | 18.68 | 29899451 | |
| 365 | N-linked_Glycosylation | DDPCLLTNRSARIPC CCCEECCCCCCCCCE | 35.56 | - | |
| 457 | N-linked_Glycosylation | LPQYRSYNDSVDPRI CHHHHCCCCCCCHHH | 36.01 | - | |
| 490 | Nitrated tyrosine | MFRLNNQYRPTGPNP HHHCCCCCCCCCCCC | 22.23 | - | |
| 711 | N-linked_Glycosylation | CNTLPKLNLTSWKET CCCCCCCCCCCCCCC | 47.61 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PERM_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PERM_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PERM_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PERM_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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