UCK1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCK1_MOUSE
• UniProt AC: P52623
• Protein Name: Uridine-cytidine kinase 1
• Gene Name: Uck1
• Organism: Mus musculus (Mouse).
• Sequence Length: 277
• Protein Description: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity)..
• Protein Sequence: MASAGGGGSESAAPEADRPQPRPFLIGVSGGTASGKSTVCEKIMELLGQNEVDRRQRKLVILSQDCFYKVLTAEQKAKALKGQYNFDHPDAFDNDLMHKTLKNIVEGKTVEVPTYDFVTHSRLPETTVVYPADVVLFEGILVFYTQEIRDMFHLRLFVDTDSDVRLSRRVLRDVQRGRDLEQILTQYTAFVKPAFEEFCLPTKKYADVIIPRGVDNMVAINLIVQHIQDILNGDLCKRHRGGPNGRNHKRTFPEPGDHPGVLATGKRSHLESSSRPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ASAGGGGSESAAPEA CCCCCCCCCCCCCCC	31.49	30635358
11	Phosphorylation	AGGGGSESAAPEADR CCCCCCCCCCCCCCC	31.28	30635358
81	Ubiquitination	EQKAKALKGQYNFDH HHHHHHHCCCCCCCC	49.15	-
99	Ubiquitination	FDNDLMHKTLKNIVE CCHHHHHHHHHHHHC	41.40	-
167	Phosphorylation	TDSDVRLSRRVLRDV CCCHHHHHHHHHHHH	13.89	23140645
251	Phosphorylation	NGRNHKRTFPEPGDH CCCCCCCCCCCCCCC	48.63	-
268	Phosphorylation	VLATGKRSHLESSSR EECCCCHHHHCCCCC	35.59	-
272	Phosphorylation	GKRSHLESSSRPH-- CCHHHHCCCCCCC--	39.72	26060331

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCK1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCK1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCK1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UCK1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.