dbPTM

FACE2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FACE2_MOUSE
UniProt AC	P57791
Protein Name	CAAX prenyl protease 2
Gene Name	Rce1
Organism	Mus musculus (Mouse).
Sequence Length	329
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity)..
Protein Sequence	MAALGGDGLRLLSVSRPERQPESAALSGPGSGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRSTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLTDGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFVSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALGGDGL ------CCCCCCCCE	16.05	-
13	Phosphorylation	GDGLRLLSVSRPERQ CCCEEEEEECCCCCC	23.73	-
15	Phosphorylation	GLRLLSVSRPERQPE CEEEEEECCCCCCCC	38.45	-
72	Phosphorylation	PAVIKRRSTSVLVVS CCCCCCCCCEEEEEC	29.12	21082442
73	Phosphorylation	AVIKRRSTSVLVVSS CCCCCCCCEEEEECC	22.50	21082442
74	Phosphorylation	VIKRRSTSVLVVSSL CCCCCCCEEEEECCC	18.07	21082442
82	Phosphorylation	VLVVSSLSPLCVLLW EEEECCCHHHHHHHH	20.13	21082442

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FACE2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
48	K	ubiquitylation	-
'Lys-48' ubiquitination induces its degradation.
48	K	ubiquitylation	-
Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FACE2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of FACE2_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FACE2_MOUSE

Related Literatures of Post-Translational Modification