AL1B1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AL1B1_MOUSE
• UniProt AC: Q9CZS1
• Protein Name: Aldehyde dehydrogenase X, mitochondrial
• Gene Name: Aldh1b1
• Organism: Mus musculus (Mouse).
• Sequence Length: 519
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity)..
• Protein Sequence: MLTARLLLPRLLCLQGRTTSYSTAAALPNPIPNPEICYNKLFINNEWHDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDLAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYVLDLDEVIKVYRYFAGWADKWHGKTIPMDGEHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHMDVDKVAFTGSTEVGHLIQKAAGESNLKRVTLELGGKSPSIVLADADMEHAVDQCHEALFFNMGQCCCAGSRTFVEESIYREFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERILGYIRLGQKEGAKLLCGGERLGERGFFIKPTVFGDVQDGMRIAKEEIFGPVQPLFKFKKIEEVIQRANNTRYGLAAAVFTRDLDKAIYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLRAYTEVKTVTIKVPEKNS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Acetylation	NPEICYNKLFINNEW CHHHCCCEEEECCCC	20.49	23576753
53	Succinylation	EWHDAVSKKTFPTVN CCHHHHHCCCCCCCC	49.59	23954790
53	Acetylation	EWHDAVSKKTFPTVN CCHHHHHCCCCCCCC	49.59	23576753
54	Acetylation	WHDAVSKKTFPTVNP CHHHHHCCCCCCCCC	48.14	23576753
54	Succinylation	WHDAVSKKTFPTVNP CHHHHHCCCCCCCCC	48.14	23806337
54	Succinylation	WHDAVSKKTFPTVNP CHHHHHCCCCCCCCC	48.14	-
83	Succinylation	ADVDLAVKAAREAFR HHHHHHHHHHHHHHH	30.62	23806337
83	Succinylation	ADVDLAVKAAREAFR HHHHHHHHHHHHHHH	30.62	-
83	Acetylation	ADVDLAVKAAREAFR HHHHHHHHHHHHHHH	30.62	23806337
181	S-palmitoylation	RHEPVGVCGQIIPWN CCCCCCCCCEECCCC	2.46	28526873
274	Acetylation	EVGHLIQKAAGESNL HHHHHHHHHHCCCCC	32.96	23576753
285	Phosphorylation	ESNLKRVTLELGGKS CCCCCEEEEECCCCC	20.67	29135757
366	Succinylation	QQGPQVDKEQFERIL CCCCCCCHHHHHHHH	55.34	-
366	Acetylation	QQGPQVDKEQFERIL CCCCCCCHHHHHHHH	55.34	23576753
366	Succinylation	QQGPQVDKEQFERIL CCCCCCCHHHHHHHH	55.34	23806337
375	Phosphorylation	QFERILGYIRLGQKE HHHHHHHHHHCCCCC	4.57	119599
381	Glutarylation	GYIRLGQKEGAKLLC HHHHCCCCCCCEEEE	57.21	24703693
381	Acetylation	GYIRLGQKEGAKLLC HHHHCCCCCCCEEEE	57.21	23201123
385	Succinylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	23806337
385	Succinylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	-
385	Acetylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	23576753
385	Glutarylation	LGQKEGAKLLCGGER CCCCCCCEEEECCCC	53.50	24703693
401	Acetylation	GERGFFIKPTVFGDV CCCCCEECCEEEECC	29.49	23576753
401	Ubiquitination	GERGFFIKPTVFGDV CCCCCEECCEEEECC	29.49	-
401	Succinylation	GERGFFIKPTVFGDV CCCCCEECCEEEECC	29.49	-
401	Succinylation	GERGFFIKPTVFGDV CCCCCEECCEEEECC	29.49	23806337
416	Succinylation	QDGMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	23806337
416	Ubiquitination	QDGMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
416	Succinylation	QDGMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	-
416	Acetylation	QDGMRIAKEEIFGPV CCCCHHHHHHHHCCC	54.21	23576753
428	Succinylation	GPVQPLFKFKKIEEV CCCHHHCCCCCHHHH	65.05	23806337
428	Succinylation	GPVQPLFKFKKIEEV CCCHHHCCCCCHHHH	65.05	-
428	Acetylation	GPVQPLFKFKKIEEV CCCHHHCCCCCHHHH	65.05	23576753
430	Acetylation	VQPLFKFKKIEEVIQ CHHHCCCCCHHHHHH	54.13	23201123
431	Succinylation	QPLFKFKKIEEVIQR HHHCCCCCHHHHHHH	59.49	23806337
431	Malonylation	QPLFKFKKIEEVIQR HHHCCCCCHHHHHHH	59.49	26320211
431	Glutarylation	QPLFKFKKIEEVIQR HHHCCCCCHHHHHHH	59.49	24703693
431	Acetylation	QPLFKFKKIEEVIQR HHHCCCCCHHHHHHH	59.49	23576753

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AL1B1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AL1B1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AL1B1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AL1B1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.