MYCT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYCT1_MOUSE
• UniProt AC: Q8R411
• Protein Name: Myc target protein 1
• Gene Name: Myct1
• Organism: Mus musculus (Mouse).
• Sequence Length: 188
• Subcellular Localization: Nucleus membrane ; Single-pass membrane protein .
• Protein Description: May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability and inhibition of hematopoietic differentiation..
• Protein Sequence: MANNTTSLGSPWPENFWEDLIMSFTVSVAIGLAIGGFLWALFVFLSRRRRASAPISQWSPTRRPRSSYNHGLNRTGFYRHSGYERRSNLSLASLTFQRQASMELVNSFPRKSSFRASTFHPFLQCPPLPVETESQLMTLSASTTPSTLSTAHSPSRPDFRWSSNSLRMGLSTPPPPAYESIIKAFPDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Phosphorylation	LSRRRRASAPISQWS HHHHHHCCCCHHHCC	32.53	22324799
56	Phosphorylation	RRASAPISQWSPTRR HHCCCCHHHCCCCCC	25.25	22345495
59	Phosphorylation	SAPISQWSPTRRPRS CCCHHHCCCCCCCCC	14.57	28542873
61	Phosphorylation	PISQWSPTRRPRSSY CHHHCCCCCCCCCHH	33.52	25159016
66	Phosphorylation	SPTRRPRSSYNHGLN CCCCCCCCHHCCCCC	39.60	22817900
67	Phosphorylation	PTRRPRSSYNHGLNR CCCCCCCHHCCCCCC	31.10	22817900
68	Phosphorylation	TRRPRSSYNHGLNRT CCCCCCHHCCCCCCC	16.66	-
81	Phosphorylation	RTGFYRHSGYERRSN CCCCCCCCCCCCCCC	33.79	24719451
87	Phosphorylation	HSGYERRSNLSLASL CCCCCCCCCCCHHHH	48.63	25521595
90	Phosphorylation	YERRSNLSLASLTFQ CCCCCCCCHHHHHHH	26.58	25521595
93	Phosphorylation	RSNLSLASLTFQRQA CCCCCHHHHHHHHHH	32.98	21082442
95	Phosphorylation	NLSLASLTFQRQASM CCCHHHHHHHHHHHH	18.41	23737553
101	Phosphorylation	LTFQRQASMELVNSF HHHHHHHHHHHHHCC	12.40	25521595
107	Phosphorylation	ASMELVNSFPRKSSF HHHHHHHCCCCCCCC	29.19	22817900
153	Phosphorylation	STLSTAHSPSRPDFR CHHHCCCCCCCCCCC	23.31	23649490
155	Phosphorylation	LSTAHSPSRPDFRWS HHCCCCCCCCCCCCC	60.50	23649490
162	Phosphorylation	SRPDFRWSSNSLRMG CCCCCCCCCCCCCCC	18.52	27180971
163	Phosphorylation	RPDFRWSSNSLRMGL CCCCCCCCCCCCCCC	24.39	23737553
165	Phosphorylation	DFRWSSNSLRMGLST CCCCCCCCCCCCCCC	21.21	27180971
171	Phosphorylation	NSLRMGLSTPPPPAY CCCCCCCCCCCCCHH	32.89	23649490
172	Phosphorylation	SLRMGLSTPPPPAYE CCCCCCCCCCCCHHH	44.87	26745281
178	Phosphorylation	STPPPPAYESIIKAF CCCCCCHHHHHHHHC	18.91	23140645
180	Phosphorylation	PPPPAYESIIKAFPD CCCCHHHHHHHHCCC	19.55	23140645
183	Ubiquitination	PAYESIIKAFPDS-- CHHHHHHHHCCCC--	42.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYCT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYCT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYCT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MYCT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87 AND SER-90, AND MASSSPECTROMETRY.
PubMed: 17242355