dbPTM

RPAC1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPAC1_MOUSE
UniProt AC	P52432
Protein Name	DNA-directed RNA polymerases I and III subunit RPAC1
Gene Name	Polr1c
Organism	Mus musculus (Mouse).
Sequence Length	346
Subcellular Localization	Nucleus .
Protein Description	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)..
Protein Sequence	MAAAQAVEEMRTRVVLGEFGVRNVHTTDFPGNYAGYDDAWDQNRFEKNFRVDVVQMDEDTLEFDMVGIDAAIANAFRRILLAEVPTMAVEKVLVYNNTSIVQDEILAHRLGLIPILADPRLFEYRNQGEEEGTEIDTLQFRLQVRCTRNPNAAKDSSDPNELYVNHKVYTRHMTWVPLGNQADVFPEGTIRPVHDDILIAQLRPGQEIDLMMHCVKGIGKDHAKFSPVATASYRLLPAITLLEPVEGEAAEELSQCFSPGVIEVEEVQGKKVARVANARLDTFSREIFRHEKLKKAVRLARVRDHYIFSVESTGVLPPDVLVSEAIKILMGKCRRFLDELDAVEMD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAQAVEE ------CHHHHHHHH	16.11	-
33	Phosphorylation	TTDFPGNYAGYDDAW CCCCCCCCCCCCCCC	13.81	22817900
224	Ubiquitination	GIGKDHAKFSPVATA CCCCCCCCCCCCHHH	42.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPAC1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPAC1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPAC1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RPAC1_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPAC1_MOUSE

Related Literatures of Post-Translational Modification